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| | 2-HYDROXY-6-(TRIFLUOROMETHYL)PYRIDINE Basic information |
| | 2-HYDROXY-6-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties |
| Melting point | 124-126° | | Boiling point | 223.7±40.0 °C(Predicted) | | density | 1.398±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | pka | 8.03±0.10(Predicted) | | color | White to Off-White | | InChI | InChI=1S/C6H4F3NO/c7-6(8,9)4-2-1-3-5(11)10-4/h1-3H,(H,10,11) | | InChIKey | XXRUAAOADAPPII-UHFFFAOYSA-N | | SMILES | C1(=O)NC(C(F)(F)F)=CC=C1 | | CAS DataBase Reference | 34486-06-1(CAS DataBase Reference) | | EPA Substance Registry System | 2(1H)-Pyridinone, 6-(trifluoromethyl)- (34486-06-1) |
| | 2-HYDROXY-6-(TRIFLUOROMETHYL)PYRIDINE Usage And Synthesis |
| Uses | 2-Hydroxy-6-trifluoromethylpyridine | | Synthesis | (3) 1500 g of tert-butanol, 140 g of potassium hydroxide and 2-chloro-6-trifluoromethylpyridine prepared in step (2) were added to a 3 L reaction flask, heated up to 70 °C, and the reaction was held for 8 hours. After completion of the reaction, tert-butanol was removed by distillation under reduced pressure, 550 g of ethyl acetate and 550 g of water were added and mixed with stirring. The organic layer was washed with 370 g of saturated brine and dried by adding 100 g of anhydrous sodium sulfate. The ethyl acetate was removed by rotary evaporation to obtain 172.4 g of crude product; (4) The crude product prepared in step (3) was dissolved in 150 g of ethyl acetate, heated to 70 °C and stirred. 1200 g of petroleum ether was added slowly dropwise and the mixture was cooled to 2°C after the dropwise addition was completed, solid crystals were precipitated and the solid was collected by filtration. The solid was washed with 50 g of petroleum ether and dried at 70 °C to give 131.2 g of 2-hydroxy-6-trifluoromethylpyridine as a light yellow solid powder in 80.8% yield. | | References | [1] Patent: CN106866512, 2017, A. Location in patent: Paragraph 0014
[2] Patent: US5973159, 1999, A
[3] Patent: CN107759513, 2018, A. Location in patent: Paragraph 0017 |
| | 2-HYDROXY-6-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials |
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