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| | 2,5-DICHLOROFLUOROBENZENE Basic information |
| Product Name: | 2,5-DICHLOROFLUOROBENZENE | | Synonyms: | 1,4-Dichloro-2-fluorobenzene, 99+%;2,5-dichloro-1-fluorobenzene;2,5-Dichlorofluorobenzene 98%;2,5-Dichlorofluorobenzene98%;2,5-DICHLOROFLUOROBENZENE;1,4-Dichloro-2-fluorobenzene, 99+% 5GR;Benzene,1,4-dichloro-2-fluoro-;2,5-dichloro-fluorophenyl | | CAS: | 348-59-4 | | MF: | C6H3Cl2F | | MW: | 164.99 | | EINECS: | | | Product Categories: | Chlorine Compounds;Fluorine Compounds;Fluorine series;Other fluorin-contained compounds | | Mol File: | 348-59-4.mol |  |
| | 2,5-DICHLOROFLUOROBENZENE Chemical Properties |
| Melting point | 4 °C | | Boiling point | 168 °C | | density | 1.383 | | refractive index | 1.5235-1.5255 | | Fp | 65 °C | | storage temp. | Sealed in dry,Room Temperature | | solubility | Difficult to mix. | | form | clear liquid | | Specific Gravity | 1.383 | | color | Colorless to Light yellow to Light orange | | BRN | 2355590 | | CAS DataBase Reference | 348-59-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26 | | RIDADR | 1992 | | Hazard Note | Irritant | | PackingGroup | III | | HS Code | 29036990 |
| | 2,5-DICHLOROFLUOROBENZENE Usage And Synthesis |
| Chemical Properties | CLEAR COLORLESS LIQUID | | Uses | 1,4-Dichloro-2-fluorobenzene is used as organic synthesis intermediates | | Synthesis | General procedure for the synthesis of 2,5-dichlorofluorobenzene from 2,5-dichloroaniline:
1. Continuous diazotization step: material A (50 mL aqueous solution containing 2,5-dichloroaniline (100 mmol), fluoboric acid (120 mmol) and hydrochloric acid (180 mmol)) was pumped through a T-fitting into a reaction tube at a flow rate of 4 mL/min at 25°C with material B (50 mL aqueous solution containing sodium nitrite (105 mmol)), the mixture flowed through the outlet and collected in a cooling vessel. Vigorous stirring was maintained. The slurry was cooled to -5 °C and then diafiltrated. The solid was washed with methanol and subsequently dried under vacuum to give 2,5-dichlorobenzenediazonium tetrafluoroborate.
2. Continuous fluorination step: a slurry of 2,5-dichlorobenzenediazonium tetrafluoroborate prepared above in 300 mL of co-solvent was introduced continuously into a reaction tube at a flow rate of 4 mL/min. The mixture was kept at the set temperature for 1 min and subsequently cooled in the tandem tube. The collected liquid was washed with aqueous NaOH and water to give an almost colorless liquid of 2,5-dichlorofluorobenzene. | | References | [1] Tetrahedron Letters, 2013, vol. 54, # 10, p. 1261 - 1263
[2] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
[3] Journal of the American Chemical Society, 1953, vol. 75, p. 4590
[4] Acta Chimica Academiae Scientiarum Hungaricae, 1957, vol. 10, p. 227,229 |
| | 2,5-DICHLOROFLUOROBENZENE Preparation Products And Raw materials |
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