- RepSox
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- $30.00
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2026-07-27
- CAS:446859-33-2
- Purity: 99.86%
- Supply Ability: 10g
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| | ALK5 inhibitor II Basic information |
| | ALK5 inhibitor II Chemical Properties |
| Melting point | 195 °C | | Boiling point | 501.9±50.0 °C(Predicted) | | density | 1.296±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >20mg/mL | | form | Yellow solid | | pka | 10.05±0.50(Predicted) | | color | Pale yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. | | InChI | InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22) | | InChIKey | LBPKYPYHDKKRFS-UHFFFAOYSA-N | | SMILES | N1C2C(=NC=CC=2)C=CC=1C1=CNN=C1C1=NC(C)=CC=C1 |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | ALK5 inhibitor II Usage And Synthesis |
| Description | RepSox (446859-33-2) is a potent (IC50ALK5 auto-P= 4 nM; IC50TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4 | | Uses | Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer. | | Uses | RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells. | | Definition | ChEBI: 1,5-naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl]- is a pyrazolopyridine. | | Biochem/physiol Actions | RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs). | | storage | +4°C | | References | [1] FRANÇOISE GELLIBERT. Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors[J]. Journal of Medicinal Chemistry, 2004, 47 18: 4494-4506. DOI:10.1021/jm0400247
[2] JUSTIN K ICHIDA. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.[J]. Cell stem cell, 2009, 5 5: 491-503. DOI:10.1016/j.stem.2009.09.012
[3] LIN CHENG. Direct conversion of astrocytes into neuronal cells by drug cocktail[J]. Cell Research, 2015, 25 11: 1269-1272. DOI:10.1038/cr.2015.120
[4] LIN CHENG. Generation of neural progenitor cells by chemical cocktails and hypoxia[J]. Cell Research, 2014, 24 6: 665-679. DOI:10.1038/cr.2014.32 |
| | ALK5 inhibitor II Preparation Products And Raw materials |
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