2-Chloro-5-methylpyrimidine

2-Chloro-5-methylpyrimidine Suppliers list

Company Name:	Liyang Kunlu biological technology co.,ltd Gold
Tel:	0519-87310015 13813530041
Email:	200601296@qq.com

Company Name:	TCI (Shanghai) Development Co., Ltd.
Tel:	021-67121386
Email:	Sales-CN@TCIchemicals.com

2-Chloro-5-methylpyrimidine manufacturers

2-Chloro-5-methylpyrimidine Basic information

Product Name:	2-Chloro-5-methylpyrimidine
Synonyms:	2-Chloro-5-methylpyrimidine;Pyrimidine, 2-chloro-5-methyl- (8CI,9CI);2-Chloro-5-methyl-1,3-diazine;2-Chloro-5-MethylpyriMidine, 97+%;2-Chlor5-Methyl pyrimidine;2-Chloro-5-methylpyrimidine 98%;2-Chloro-5-methylpyrimidine >;Pyrimidine, 2-chloro-5-methyl-
CAS:	22536-61-4
MF:	C5H5ClN2
MW:	128.56
EINECS:	807-915-1
Product Categories:	Heterocycle-Pyrimidine series;PYRIMIDINE;pharmacetical;Pyrimidine series
Mol File:	22536-61-4.mol

2-Chloro-5-methylpyrimidine Chemical Properties

Melting point	89-92℃
Boiling point	239.2±9.0 °C(Predicted)
density	1.234±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	-1.03±0.22(Predicted)
form	Solid
color	White to Light yellow
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C5H5ClN2/c1-4-2-7-5(6)8-3-4/h2-3H,1H3
InChIKey	APRMCBSTMFKLEI-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(C)C=N1
CAS DataBase Reference	22536-61-4(CAS DataBase Reference)

Safety Information

MSDS Information

2-Chloro-5-methylpyrimidine Usage And Synthesis

Uses	Used in organic synthesis, catalytic agent, petrochemical additive and synthetic chemistry. Also used as intermediate for pharmaceutical.
Synthesis	1780-31-0 22536-61-4 Step 1. Synthesis of 2-chloro-5-methylpyrimidine To a stirred solution of 2,4-dichloro-5-methylpyrimidine (4.00 g, 24.5 mmol) dissolved in a solvent mixture of benzene (16.0 mL) and water (40.0 mL) was added zinc powder (4.81 g, 73.6 mmol) and ammonia (8.80 mL, 24.5 mmol) sequentially at room temperature. The reaction mixture was heated and refluxed for 18 hours, then cooled to room temperature and filtered through a diatomaceous earth pad. The filtrate was extracted with ether (Et2O), and the combined organic phases were washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 1:1) to afford the target compound 2-chloro-5-methylpyrimidine (2.44 g, 77% yield) as a yellow oil.1H NMR (400 MHz, CDCl3) δ 2.33 (3H, s), 8.47 (2H, s).
References	[1] Patent: WO2013/132376, 2013, A1. Location in patent: Page/Page column 224 [2] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4720 - 4744 [3] Patent: US2012/53180, 2012, A1. Location in patent: Page/Page column 8 [4] Patent: US2010/190771, 2010, A1. Location in patent: Page/Page column 33 [5] Patent: US2008/306082, 2008, A1. Location in patent: Page/Page column 26-27

2-Chloro-5-methylpyrimidine Preparation Products And Raw materials

Raw materials	2-Hydroxy-5-methylpyrimidine-->2,4-Dichloro-5-methylpyrimidine-->Ammonium hydroxide-->Benzene-->ZINC
Preparation Products	Pyridine, 5-(bromomethyl)-2-chloro- (9CI)-->Pyrimidine, 2-chloro-5-(trifluoromethyl)- (9CI)-->4-Piperidinol, 1-(5-methyl-2-pyrimidinyl)--->1,5-Dimethylpyrimidin-2(1H)-one-->2(1H)-Pyrimidinone, 5-methyl-, hydrazone (8CI,9CI)-->5-(broMoMethyl)-2-chloropyriMidine

Tag:2-Chloro-5-methylpyrimidine(22536-61-4) Related Product Information

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