| Company Name: |
SPIRO PHARMA |
| Tel: |
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| Email: |
eric_feng1954@126.com |
SodiuM Channel inhibitor 1 manufacturers
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| | SodiuM Channel inhibitor 1 Basic information |
| Product Name: | SodiuM Channel inhibitor 1 | | Synonyms: | SodiuM Channel inhibitor 1;7-Fluoro-2,3-dihydro-3-oxo-2-[2-(2-pyridinyl)ethyl]-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindole-1-carboxamide;CS-1478;1H-Isoindole-1-carboxamide, 7-fluoro-2,3-dihydro-3-oxo-2-[2-(2-pyridinyl)ethyl]-N-[[4-(trifluoromethoxy)phenyl]methyl]-;7-Fluoro-3-oxo-2-(2-(pyridin-2-yl)ethyl)-n-(4-(trifluoromethoxy)benzyl)isoindoline-1-carboxamide | | CAS: | 1198117-23-5 | | MF: | C24H19F4N3O3 | | MW: | 473.42 | | EINECS: | | | Product Categories: | | | Mol File: | 1198117-23-5.mol |  |
| | SodiuM Channel inhibitor 1 Chemical Properties |
| Boiling point | 629.6±55.0 °C(Predicted) | | density | 1.380±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Powder | | pka | 13.07±0.20(Predicted) | | color | White to off-white |
| | SodiuM Channel inhibitor 1 Usage And Synthesis |
| Uses | Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment.
IC50 Value: 0.16 uM ( Na v1.7, V hold-90mV); 0.41 uM (Na v1.7, V hold-90mV) [1]
Target: Na v1.7
Sodium Channel inhibitor1 demonstrated concentration-dependent efficacy in preclinical behavioral pain models. | | References | [1] Macsari I, et al. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7with efficacy in rat pain models. J Med Chem. 2012 Aug 9;55(15):6866-80. DOI:10.1021/jm300623u |
| | SodiuM Channel inhibitor 1 Preparation Products And Raw materials |
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