- DL-Ser-OMe·HCl
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2026-09-15
- CAS:5619-04-5
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
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| | Methyl-DL-serine hydrochloride Basic information |
| | Methyl-DL-serine hydrochloride Chemical Properties |
| Melting point | 134-136 °C(lit.) | | density | 1.37g/cm3 at 20℃ | | storage temp. | -20°C | | solubility | Methanol, Water | | form | Solid | | color | White to Off-White | | Sensitive | Moisture Sensitive | | BRN | 6067970 | | Major Application | peptide synthesis | | InChI | InChI=1S/C4H9NO3.ClH/c1-8-4(7)3(5)2-6;/h3,6H,2,5H2,1H3;1H | | InChIKey | NDBQJIBNNUJNHA-UHFFFAOYSA-N | | SMILES | C(N)(CO)C(=O)OC.Cl | | LogP | -2 at 20℃ and pH7 | | Surface tension | 76mN/m at 1g/L and 20℃ | | CAS DataBase Reference | 5619-04-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-24/25 | | WGK Germany | 3 | | HS Code | 29225000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Methyl-DL-serine hydrochloride Usage And Synthesis |
| Chemical Properties | white crystalline powder | | Uses | D,L-Serine Methyl Ester Hydrochloride is used as a reactant in the preparation of chicoric acid analogs as HIV-1 integrase inhibitors. Also used in the total synthesis of (-)-Hennoxazole A. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | 100 mL of methanol was added to a 30 mL triple-necked vial placed on a mechanical stirrer and cooled in an ice-water bath. 6.6 ml of dichlorosulfoxide was slowly added dropwise and stirring was continued for 1 hour after completion of the dropwise addition. Subsequently, 6.00 g (57 mmol) of DL-serine was added to the reaction system. The reaction mixture was heated to reflux and the reaction was continued for 18 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The product was dried to give 8.32 g of DL-serine methyl ester hydrochloride in 94.2% yield. | | References | [1] Heterocycles, 2012, vol. 86, # 2, p. 1575 - 1582
[2] Patent: CN105777611, 2016, A. Location in patent: Paragraph 0048; 0049
[3] Australian Journal of Chemistry, 1994, vol. 47, # 5, p. 903 - 912
[4] Journal of the Chemical Society. Perkin Transactions 2, 1997, # 3, p. 503 - 507
[5] Journal of the American Chemical Society, 2010, vol. 132, # 7, p. 2274 - 2283 |
| | Methyl-DL-serine hydrochloride Preparation Products And Raw materials |
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