- L-Prolinamide
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2026-10-13
- CAS:7531-52-4
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 500kg
- L-Prolinamide
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- $5.00
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2026-09-02
- CAS:7531-52-4
- Min. Order: 1KG
- Purity: 99%
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| | L-Prolinamide Chemical Properties |
| Melting point | 95-97 °C (lit.) | | alpha | -106 º (c=2, EtOH) | | Boiling point | 213.66°C (rough estimate) | | density | 1.1008 (rough estimate) | | refractive index | 1.4720 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 16.21±0.20(Predicted) | | form | Powder or Granules | | color | White to straw | | Optical Rotation | [α]20/D 106°, c = 2 in ethanol | | Water Solubility | Soluble in water and ethanol (50 mg/ml). | | BRN | 80807 | | Major Application | peptide synthesis | | InChI | 1S/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)/t4-/m0/s1 | | InChIKey | VLJNHYLEOZPXFW-BYPYZUCNSA-N | | SMILES | NC(=O)[C@@H]1CCCN1 | | CAS DataBase Reference | 7531-52-4(CAS DataBase Reference) |
| | L-Prolinamide Usage And Synthesis |
| Synthesis | 20% Pd(OH)₂/C (Pearlman catalyst, 80 mg) was added to a solution of the aminoamide adduct (175 mg, 0.8 mmol) in an EtOH/AcOH (1:1) (4 mL) mixture. The mixture was stirred at room temperature under H₂ (1 atm) for 14 hours. The mixture was degassed under an argon flow and filtered through diatomaceous earth. The collected solids were washed with EtOH (3 x 10 mL). The combined filtrate and washes were concentrated. The residue was neutralized with concentrated NH₄OH (2 mL). The mixture was placed in FC (eluent, MeOH/CH₂Cl₂/concentrated NH₄OH 50/50/1) to give L-prolylamide.
 Figure 1 Synthetic route of L-Prolinamide | | Chemical Properties | Crystalline | | Uses | Proline based organocatalyst. | | Uses | It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. Also it is a efficient organocatalysts for aldol reactions on water. | | Definition | ChEBI: The carboxamide derivative of L-proline. | | reaction suitability | reaction type: solution phase peptide synthesis |
| | L-Prolinamide Preparation Products And Raw materials |
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