| Company Name: |
Amatek Scientific Co. Ltd.
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| Tel: |
0512-56316828 400-867-5858;400-867-5858 |
| Email: |
info@amateksci.com |
| Products Intro: |
Product Name:tert-Butyl [2-(2-aminoethoxy)ethoxy]carbamate
CAS:1844894-82-1
Purity:97% HPLC Package:1g;5g;25g;100g
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t-Boc-Aminooxy-PEG1-amine manufacturers
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| | t-Boc-Aminooxy-PEG1-amine Basic information |
| Product Name: | t-Boc-Aminooxy-PEG1-amine | | Synonyms: | t-Boc-Aminooxy-PEG1-amine;Boc-Aminooxy-PEG1-C2-NH2;Carbamic acid, N-[2-(2-aminoethoxy)ethoxy]-, 1,1-dimethylethyl ester;t-Boc-Aminooxy-PEG1-amine boc-;tert-Butyl [2-(2-aminoethoxy)ethoxy]carbamate | | CAS: | 1844894-82-1 | | MF: | C9H20N2O4 | | MW: | 220.27 | | EINECS: | | | Product Categories: | | | Mol File: | 1844894-82-1.mol |  |
| | t-Boc-Aminooxy-PEG1-amine Chemical Properties |
| density | 1.070±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DCM | | pka | 8.74±0.10(Predicted) |
| | t-Boc-Aminooxy-PEG1-amine Usage And Synthesis |
| Description | t-Boc-Aminooxy-PEG1-amine is a PEG linker containing a Boc-protected aminooxy group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde or ketone group to form a stable oxime linkage. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. | | Uses | Boc-Aminooxy-PEG1-C2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | t-Boc-Aminooxy-PEG1-amine Preparation Products And Raw materials |
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