t-boc-N-amido-PEG4-NHS ester manufacturers
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| | t-boc-N-amido-PEG4-NHS ester Basic information |
| Product Name: | t-boc-N-amido-PEG4-NHS ester | | Synonyms: | 5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(1,1-dimethylethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester;BocNH-PEG4-CH2CH2COONHS;CAS_859230-20-9;t-boc-N-amido-PEG4-NHS ester;Boc-NH-PEG4-SPA;Boc-NH-PEG4-NHS ester;BocNH-P5-NHS ester;BocNH-PEG4-CH2CH2COONHS/5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(1,1-dimethylethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester | | CAS: | 859230-20-9 | | MF: | C20H34N2O10 | | MW: | 462.49 | | EINECS: | | | Product Categories: | | | Mol File: | 859230-20-9.mol |  |
| | t-boc-N-amido-PEG4-NHS ester Chemical Properties |
| storage temp. | Storage temp. -20°C | | solubility | Soluble in DMSO, DCM, DMF | | form | Viscous Liquid | | color | Colorless to light yellow |
| | t-boc-N-amido-PEG4-NHS ester Usage And Synthesis |
| Description | t-Boc-N-amido-PEG4-NHS ester is a PEG linker containing a Boc-protected amine group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The protected amine can be deprotected by acidic conditions. | | Uses | Boc-NH-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | t-boc-N-amido-PEG4-NHS ester Preparation Products And Raw materials |
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