t-Boc-N-amido-PEG1-NHS ester manufacturers
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| | t-Boc-N-amido-PEG1-NHS ester Basic information |
| Product Name: | t-Boc-N-amido-PEG1-NHS ester | | Synonyms: | t-Boc-N-amido-PEG1-NHS ester;BocNH-PEG1-CH2CH2COONHS;Boc-N-PEG1-C2-NHS ester;2,5-Dioxopyrrolidin-1-yl 3-(2-((tert-butoxycarbonyl)amino)ethoxy)propanoate;BocNH-PEG1-CH2CH2COONHS/Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester;Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester;BocNH-PEG1-CH2CH2COONHS ester;t-Boc-N-amido-PEG1-NHS | | CAS: | 1260092-55-4 | | MF: | C14H22N2O7 | | MW: | 330.33 | | EINECS: | | | Product Categories: | | | Mol File: | 1260092-55-4.mol |  |
| | t-Boc-N-amido-PEG1-NHS ester Chemical Properties |
| density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Storage temp. -20°C | | pka | 12.21±0.46(Predicted) | | form | Solid | | color | White to off-white |
| | t-Boc-N-amido-PEG1-NHS ester Usage And Synthesis |
| Description | t-Boc-N-amido-PEG1-NHS ester is a PEG linker containing NHS ester and Boc-protected amine moieties. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc group can be deprotected under mild acidic conditions to form a free amine. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | | Uses | Boc-N-PEG1-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | t-Boc-N-amido-PEG1-NHS ester Preparation Products And Raw materials |
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