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| | 2-Fluoro-6-nitrobenzoic acid Basic information |
| | 2-Fluoro-6-nitrobenzoic acid Chemical Properties |
| Melting point | 150 °C | | Boiling point | 334.7±27.0 °C(Predicted) | | density | 1.568±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 1.50±0.30(Predicted) | | form | Solid | | color | White to Light yellow to Light orange | | CAS DataBase Reference | 385-02-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 29163900 |
| | 2-Fluoro-6-nitrobenzoic acid Usage And Synthesis |
| Chemical Properties | light yellow powder | | Uses | 2-Fluoro-6-nitrobenzoic acid is used as an intermediate in the synthesis of certain drugs, pesticides or advanced materials. | | Synthesis | A. Synthesis of 2-fluoro-6-nitrobenzoic acid. Under stirring, 2-fluoro-6-nitrotoluene (exact amount not provided) was added to a suspension of potassium permanganate (102 g, 0.65 mol) in water (1.4 L). The reaction mixture was heated to reflux for 4 h, subsequently cooled to room temperature, filtered and washed with diethyl ether. The aqueous phase was acidified to pH 2 with concentrated hydrochloric acid and then extracted with ethyl acetate. The organic phase was washed with brine, dried over magnesium sulfate, filtered, and concentrated under vacuum to give 11.81 g (40% yield) of 2-fluoro-6-nitrobenzoic acid. The product was characterized by 1H NMR and IS-MS (m/e 184.0 [M-1]). Elemental analysis (C7H4FNO4) Calculated values: C, 45.42; H, 2.18; N, 7.57; Measured values: C, 45.22; H, 2.29; N, 7.27. | | References | [1] Chemische Berichte, 1896, vol. 29, p. 841
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 6, p. 758 - 768
[3] Israel Journal of Chemistry, 1964, vol. 2, p. 25 - 28
[4] Patent: US6635657, 2003, B1
[5] Patent: US4316839, 1982, A |
| | 2-Fluoro-6-nitrobenzoic acid Preparation Products And Raw materials |
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