|
|
| | 3-(Trifluoromethyl)phenyl isocyanate Basic information | | Synthesis |
| Product Name: | 3-(Trifluoromethyl)phenyl isocyanate | | Synonyms: | 1-isocyanato-3-(trifluoromethyl)-benzen;1-Isocyanato-3-(trifluoromethyl)benzene;3-Trifluoromethylphenylcyanate;alpha,alpha,alpha-Trifluoro-3-tolyl isocyanate;alpha,alpha,alpha-Trifluoro-meta-tolylisocyanate;benzene-1-isocyanato-3-(trifluoromethyl)-;Isocyanic acid m-trifluoromethylphenyl ester;Isocyanic acid, alpha,alpha,alpha-trifluoro-m-tolyl ester | | CAS: | 329-01-1 | | MF: | C8H4F3NO | | MW: | 187.12 | | EINECS: | 206-341-3 | | Product Categories: | Phenyl isocyanate&Phenyl isothiocyanate | | Mol File: | 329-01-1.mol |  |
| | 3-(Trifluoromethyl)phenyl isocyanate Chemical Properties |
| | 3-(Trifluoromethyl)phenyl isocyanate Usage And Synthesis |
| Synthesis | The preparation method is as follows: adding 3-trifluoromethylaniline and chlorobenzene to the reaction flask, stirring, mixing and dissolving it, cooling to 0-10° C., introducing dry hydrogen chloride to make it saturated, and then adding N,N-diisopropylamine. Butyl chloromethylamide, heated to 50°C and kept for 30min, and then introduced phosgene. After a certain amount of phosgene was introduced, the reaction was completed. Then the material is distilled and desolubilized to obtain the finished product. | | Chemical Properties | colorless to light yellow liquid | | Uses | 3-?(Trifluoromethyl)?phenyl Isocyanate is a reagent used in the synthesis of heme-regulated inhibitor as selective activators of the eukaryotic inhibition factor Alpha (eIF2α) phosphorylation arm of the endoplasmic reticulum stress response. Influences cell proliferation, cell differentiaton and adaptation to stress. Also a reagent in the preparation of sorafenib derivatives. | | Flammability and Explosibility | Not classified | | Safety Profile | Moderately toxic by
ingestion, inhalation, and intraperitoneal
routes. A lachrymator. Flammable liquid
when exposed to heat, sparks, or flame.
When heated to decomposition it emits very
toxic fumes of NOx and F-. See also
ISOCYANATES and FLUORIDES. |
| | 3-(Trifluoromethyl)phenyl isocyanate Preparation Products And Raw materials |
|