| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
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| | 2-Amino-5-chloro-3-fluoropyridine Basic information |
| | 2-Amino-5-chloro-3-fluoropyridine Chemical Properties |
| Melting point | 91-95 °C | | Boiling point | 195.9±35.0 °C(Predicted) | | density | 1.449±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | solid | | pka | 1.72±0.49(Predicted) | | Appearance | White to light brown Solid | | InChI | 1S/C5H4ClFN2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9) | | InChIKey | FPUPPVDVOFJSEP-UHFFFAOYSA-N | | SMILES | Nc1ncc(Cl)cc1F |
| Hazard Codes | T,Xi | | Risk Statements | 23/24/25-50 | | Safety Statements | 36/37-38-45-61-63 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 2 | | HazardClass | IRRITANT | | HS Code | 29333990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Aquatic Acute 1
Eye Irrit. 2 |
| | 2-Amino-5-chloro-3-fluoropyridine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-amino-3-fluoro-5-chloropyridine from 2,3-difluoro-5-chloropyridine: 5-chloro-2,3-difluoropyridine (100 g, 0.669 mol) and liquid ammonia (1.125 L, 8.025 mol) were placed in an autoclave. The kettle was sealed and the reaction was carried out at 120 °C for 24 hours. Upon completion of the reaction, the reaction mixture was cooled and formation of a yellowish solid precipitate was observed. The precipitate was separated by filtration and the filter cake was washed with deionized water. The filtrate was extracted with ethyl acetate, the organic layers were combined and dried with anhydrous sodium sulfate. Subsequently, the organic solvent was removed by distillation under reduced pressure, and a small amount of petroleum ether was added to the residue, which was filtered again to obtain a precipitate of the target compound 2-amino-3-fluoro-5-chloropyridine. The final product was obtained as 84.22 g in 85.94% yield. | | References | [1] Patent: CN105669539, 2016, A. Location in patent: Paragraph 0058; 0059; 0060
[2] Patent: US2008/242695, 2008, A1. Location in patent: Page/Page column 34 |
| | 2-Amino-5-chloro-3-fluoropyridine Preparation Products And Raw materials |
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