Tos-PEG3-CH2CO2tBu manufacturers
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| | Tos-PEG3-CH2CO2tBu Basic information |
| Product Name: | Tos-PEG3-CH2CO2tBu | | Synonyms: | Tos-PEG3-CH2CO2tBu;Tos-PEG2-CH2COOtBu;tert-butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate;2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]-Acetic acid, 1,1-dimethylethyl;Tos-PEG2-CH2-Boc;Acetic acid, 2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester;{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-acetic acid tert-butyl ester;Tos-PEG2-CH2COOtBu/Acetic acid, 2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester | | CAS: | 882518-89-0 | | MF: | C17H26O7S | | MW: | 374.45 | | EINECS: | | | Product Categories: | | | Mol File: | 882518-89-0.mol |  |
| | Tos-PEG3-CH2CO2tBu Chemical Properties |
| Boiling point | 484.027±35.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.175±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at Room Tem. | | solubility | Soluble in DMSO, DCM, DMF | | form | Liquid | | color | Colorless to light yellow |
| | Tos-PEG3-CH2CO2tBu Usage And Synthesis |
| Description | Tos-PEG3-CH2CO2tBu is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | | Uses | Tos-PEG2-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6 |
| | Tos-PEG3-CH2CO2tBu Preparation Products And Raw materials |
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