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| | Tos-PEG4-CH2CO2H Basic information |
| Product Name: | Tos-PEG4-CH2CO2H | | Synonyms: | Tos-PEG4-CH2CO2H;Tos-PEG3-CH2COOH;Acetic acid, 2-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-;2-[2-[2-[2-(Tosyloxy)ethoxy]ethoxy]ethoxy]acetic Acid;2-[2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethoxy]acetic acid;2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]acetic acid | | CAS: | 1581248-63-6 | | MF: | C15H22O8S | | MW: | 362.4 | | EINECS: | | | Product Categories: | | | Mol File: | 1581248-63-6.mol |  |
| | Tos-PEG4-CH2CO2H Chemical Properties |
| Boiling point | 539.9±45.0 °C(Predicted) | | density | 1.280±0.06 g/cm3(Predicted) | | solubility | Soluble in DCM | | pka | 3.39±0.10(Predicted) |
| | Tos-PEG4-CH2CO2H Usage And Synthesis |
| Description | Tos-PEG4-CH2CO2H is a PEG linker containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. | | Uses | Tos-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6 |
| | Tos-PEG4-CH2CO2H Preparation Products And Raw materials |
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