ML-180

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ML-180 Suppliers list
Company Name: Jingmo (Xiamen) Biotechnology Co., Ltd  Gold
Tel: 13621943973; 13621943973
Email: sales@jamxmpharmatech.com
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Company Name: Guangzhou Isun Pharmaceutical Co., Ltd  
Tel: 020-39119399 18927568969
Email: isunpharm@qq.com
Company Name: Bide Pharmatech Ltd.  
Tel: 400-164-7117 18317119277
Email: product02@bidepharm.com
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
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ML-180 manufacturers

  • ML-180
  • ML-180 pictures
  • $70.00
  • 2026-07-24
  • CAS:863588-32-3
  • Purity: 99.83%
  • Supply Ability: 10g
  • ML-180
  • ML-180 pictures
  • $70.00
  • 2026-07-15
  • CAS:863588-32-3
  • Purity: 99.83%
  • Supply Ability: 10g
ML-180 Basic information
Product Name:ML-180
Synonyms:SR1848;ML-180;6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione;2,4(1H,3H)-Pyrimidinedione, 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-;6-(4-(3-chlorophenyl)piperazin-1-yl)-3-cyclohexylpyrimidine-2,4(1H,3H)-dione;SR1848 >=98% (HPLC);ML-180 (SR1848);6-[4-(3-Chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine- ,4(1H,3H)dione
CAS:863588-32-3
MF:C20H25ClN4O2
MW:388.89
EINECS:
Product Categories:
Mol File:863588-32-3.mol
ML-180 Structure
ML-180 Chemical Properties
density 1.312±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 10 mg/ml
form A crystalline solid
pka9.37±0.40(Predicted)
color Off-white to light yellow
InChIInChI=1S/C20H25ClN4O2/c21-15-5-4-8-17(13-15)23-9-11-24(12-10-23)18-14-19(26)25(20(27)22-18)16-6-2-1-3-7-16/h4-5,8,13-14,16H,1-3,6-7,9-12H2,(H,22,27)
InChIKeyCHMQQIFPOIZPIJ-UHFFFAOYSA-N
SMILESC1(=O)NC(N2CCN(C3=CC=CC(Cl)=C3)CC2)=CC(=O)N1C1CCCCC1
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
MSDS Information
ML-180 Usage And Synthesis
DescriptionML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1, IC50 = 3.7 μM) with maximum efficacy of 64% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.05 μM).
UsesML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers[1][2].
DefinitionChEBI: 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione is a member of piperazines.
in vivo

ML-180 (SR1848; 30 mg/kg; i.p.; daily; for 10 days) has a statistically significant decrease of both LRH-1 and SHP mRNA in adrenal glands and pancreatic tissue[2].

Animal Model:8-week-old C57Bl/6J mice[2]
Dosage:30 mg/kg
Administration:IP; daily; for 10 days
Result:Had a statistically significant decrease of both LRH-1 and SHP mRNA in adrenal glands and pancreatic tissue.
References[1] Busby S, et al. Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2). PMID:23166964
[2] Corzo CA, et al. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1. Mol Pharmacol. 2015 Feb;87(2):296-304. DOI:10.1124/mol.114.095554
ML-180 Preparation Products And Raw materials
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