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| | 2,4-Dichloro-5-methoxypyrimidine Basic information |
| Product Name: | 2,4-Dichloro-5-methoxypyrimidine | | Synonyms: | 2,4-Dichloro-5-methoxy-1,3-diazine, 2,4-Dichloropyrimidin-5-yl methyl ether;2,4- twochloro -5-MethoxypyriMidine;5-METHOXY-2,4-DICHLORO PYRIMIDINE;2,4-DICHLORO-5-METHOXYPYRIMIDINE, 98+%;2,4-Dichloro-5-methoxypyrimidine;2,4-AICHLORO-5-METHOXY PYRIMIDINE;2,4-Dichloro-5-methoxpyrimidine;5-Methoxy-2,4-Dichloropyrimidine pyrimidine | | CAS: | 19646-07-2 | | MF: | C5H4Cl2N2O | | MW: | 179 | | EINECS: | 628-558-6 | | Product Categories: | Building Blocks;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Heterocycle-Pyrimidine series;APIs & Intermediate;Pyrimidine;Pyridines, Pyrimidines, Purines and Pteredines;Aromatics;Heterocycles;19646-07-2 | | Mol File: | 19646-07-2.mol |  |
| | 2,4-Dichloro-5-methoxypyrimidine Chemical Properties |
| Melting point | 66-70 °C | | Boiling point | 259.9±20.0 °C(Predicted) | | density | 1.446±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | -2.67±0.29(Predicted) | | form | powder to crystal | | color | White to Almost white | | Water Solubility | Slightly soluble in water. | | InChI | InChI=1S/C5H4Cl2N2O/c1-10-3-2-8-5(7)9-4(3)6/h2H,1H3 | | InChIKey | ZTHHRSBDBPCCMZ-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=C(OC)C(Cl)=N1 | | CAS DataBase Reference | 19646-07-2(CAS DataBase Reference) |
| Hazard Codes | Xi,C,Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | Hazard Note | Harmful | | HazardClass | IRRITANT, CORROSIVE | | HS Code | 29335990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 2,4-Dichloro-5-methoxypyrimidine Usage And Synthesis |
| Uses | 2,4-Dichloro-5-methoxypyrimidine can be used for preparation of heteroarylpiperazine derivatives for use in treatment of Alzheimer's disease. | | Uses | It is used for preparation of heteroarylpiperazine derivatives for use in treatment of Alzheimer's disease. | | Synthesis | The general procedure for the synthesis of 2,4-dichloro-5-methoxypyrimidines from 5-methoxy-2,4-dihydroxypyrimidines was as follows: 5-methoxy-2,4-dihydroxypyrimidines (45 g, 0.316 mol), phosphorus trichloride (225 mL, 0.88 mol), and N,N-dimethylaniline (45 mL, 0.391 mol) were mixed, and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the mixture was quenched by slowly pouring it into crushed ice (80 g). The product was extracted with ether and subsequently purified by recrystallization from light petroleum ether (boiling point: 40-60 °C) to afford 2,4-dichloro-5-methoxypyrimidine (43 g, 75% yield). Results of mass spectrometry analysis: (ES+) m/z 179 [M+H]+. | | References | [1] Journal of Organic Chemistry, 2011, vol. 76, # 10, p. 4149 - 4153
[2] Patent: WO2011/144577, 2011, A1. Location in patent: Page/Page column 24
[3] Patent: WO2011/80568, 2011, A2. Location in patent: Page/Page column 109-110
[4] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 26; 27 |
| | 2,4-Dichloro-5-methoxypyrimidine Preparation Products And Raw materials |
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