Aminooxy-PEG4-alcohol manufacturers
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| | Aminooxy-PEG4-alcohol Basic information |
| Product Name: | Aminooxy-PEG4-alcohol | | Synonyms: | Aminooxy-PEG4-alcohol;Ethanol, 2-[2-[2-[2-(aminooxy)ethoxy]ethoxy]ethoxy]-;2-(2-(2-(2-(aminooxy)ethoxy)ethoxy)ethoxy)ethanol;Aminooxy PEG4 alcohol,AminooxyPEG4alcohol,Aminooxy-PEG-4-alcohol;HO-PEG4-ONH2;Hydroxylamine-tetraethylene glycol;NH2O-PEG4-OH | | CAS: | 106492-60-8 | | MF: | C8H19NO5 | | MW: | 209.24 | | EINECS: | | | Product Categories: | | | Mol File: | 106492-60-8.mol |  |
| | Aminooxy-PEG4-alcohol Chemical Properties |
| | Aminooxy-PEG4-alcohol Usage And Synthesis |
| Description | Aminooxy-PEG4-alcohol is an aqueous soluble PEG reagent. The aminooxy group can react with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | | Uses | Aminooxy-PEG4-alcohol is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG4-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. | | IC 50 | PEGs; Non-cleavable Linker | | References | [1] Heather D. Maynard, et al. Method of creating hydrogels through oxime bond formation. US20150202305A1.
[2] Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb). 2010 Dec 7;46(45):8651-3. DOI:10.1039/c0cc03856c |
| | Aminooxy-PEG4-alcohol Preparation Products And Raw materials |
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