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| | Aminooxy-PEG3-t-butyl ester Basic information |
| Product Name: | Aminooxy-PEG3-t-butyl ester | | Synonyms: | Aminooxy-PEG3-t-butyl ester;Aminooxy-PEG3-C2-Boc;Propanoic acid, 3-[2-[2-[2-(aminooxy)ethoxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester;Aminooxy-PEG3-t-Bu Ester | | CAS: | 1835759-72-2 | | MF: | C13H27NO6 | | MW: | 293.36 | | EINECS: | | | Product Categories: | | | Mol File: | 1835759-72-2.mol |  |
| | Aminooxy-PEG3-t-butyl ester Chemical Properties |
| Boiling point | 392.4±32.0 °C(Predicted) | | density | 1.063±0.06 g/cm3(Predicted) | | pka | 4.21±0.70(Predicted) |
| | Aminooxy-PEG3-t-butyl ester Usage And Synthesis |
| Description | Aminooxy-PEG3-t-butyl ester is an aminooxy-containing PEG molecule. The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy group is reactive with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The t-butyl ester can be converted tofree acid under acidic condition. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | | Uses | Aminooxy-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Aminooxy-PEG3-t-butyl ester Preparation Products And Raw materials |
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