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| | 2-Propyl-4-pentenoic acid Basic information |
| | 2-Propyl-4-pentenoic acid Chemical Properties |
| Boiling point | 95-100 °C(Press: 5 Torr) | | density | 0.943±0.06 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Methanol: Slightly Soluble | | form | An oil | | pka | 4.70±0.20(Predicted) | | color | Colorless to light yellow | | Stability: | Toxic |
| Toxicity | LD50 intraperitoneal in mouse: 1160mg/kg |
| | 2-Propyl-4-pentenoic acid Usage And Synthesis |
| Description | (±)-2-propyl-4-Pentenoic acid (4-ene VPA) is a major metabolite of valproic acid . It undergoes β-oxidation to form reactive metabolites that induce hepatotoxicity in rats. 4-ene VPA is also neuroteratogenic, reducing forebrain size and inducing deformation of the neural tube in mouse embryos. | | Chemical Properties | Clear Colorless Oil | | Uses | A metabolite of Valproic Acid | | Definition | ChEBI: 2-n-Propyl-4-pentenoic acid is a methyl-branched fatty acid. | | Hazard | Moderately toxic. | | References | [1] W TANG F S A. A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics.[J]. Drug Metabolism and Disposition, 1997, 25 2: 219-227.
[2] F. GOFFLOT . In vitro neuroteratogenicity of valproic acid and 4-en-VPA[J]. Neurotoxicology and teratology, 1995, 17 4: Pages 425-435. DOI: 10.1016/0892-0362(94)00094-t |
| | 2-Propyl-4-pentenoic acid Preparation Products And Raw materials |
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