- 5-Methylnicotinic acid
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- $1.10
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2026-08-20
- CAS:3222-49-9
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
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| | 5-Methylnicotinic acid Basic information |
| | 5-Methylnicotinic acid Chemical Properties |
| Melting point | 210-212°C | | Boiling point | 303.9±22.0 °C(Predicted) | | density | 1.230±0.06 g/cm3(Predicted) | | vapor pressure | 0.328Pa at 25℃ | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Sparingly soluble (0.083 g/L at 25°C). | | pka | 2.27±0.10(Predicted) | | form | Solid:particulate/powder | | Appearance | White to off-white Solid | | BRN | 112288 | | InChI | InChI=1S/C7H7NO2/c1-5-2-6(7(9)10)4-8-3-5/h2-4H,1H3,(H,9,10) | | InChIKey | DJDHHXDFKSLEQY-UHFFFAOYSA-N | | SMILES | C1=NC=C(C)C=C1C(O)=O | | LogP | 1.23 | | CAS DataBase Reference | 3222-49-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Provider | Language |
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ALFA
| English |
| | 5-Methylnicotinic acid Usage And Synthesis |
| Chemical Properties | Solid | | Uses | 5-Methylnicotinic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals. | | Synthesis | 5-Methylnicotinic acid can be prepared by a one-step reaction under the condition of aqueous solvent, using 3,5-dimethylpyridine as the starting material and potassium permanganate as the oxidising agent, and reacted under mild conditions. The specific preparation method is as follows:
A, to 1200L running water is added in 2000L enamel reaction stills, then squeeze into 3,5- lutidines 120kg, stir, Between 25-35°C of temperature control, and 300kg potassium permanganate is added with 4.5h, be then incubated 30°C of reaction 16h；
B, filter core filter by-product manganese dioxide, and filtrate adjusts pH0.5 with concentrated hydrochloric acid；
C, centrifugation filter by-product 3, and 5- pyridinedicarboxylic acids, filtrate continuation adjusts PH3.0, crude product is collected by centrifugation with concentrated hydrochloric acid；
D, drying, crude product 1200L ethanol are heated to 80°C of dissolvings, heat filtering, and filtrate is cooled to 0-5°C of stirring 2h, from The heart, in drying 8.5h at 65°C, you can.The purity of final product is 99.5%.
| | References | [1] Patent: US2009/54395, 2009, A1. Location in patent: Page/Page column 42
[2] Patent: EP1193265, 2002, A2. Location in patent: Page 72
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 17, p. 2697 - 2703
[4] Journal of Chemical Research, Miniprint, 1987, # 9, p. 2360 - 2384 |
| | 5-Methylnicotinic acid Preparation Products And Raw materials |
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