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| | 3,5-Lutidine Basic information |
| Product Name: | 3,5-Lutidine | | Synonyms: | pyridine,3,5-dimethyl-;Lutidine,98%;3 5-LUTIDINE STANDARD FOR GC;3,5-LUTIDINE, 98+%;3,5-DIMETHYLPYRIDINE 98+%;3,5-Dimetylpyridine;3,5-Lutidine,99%;3,5-dimethyl-pyridin | | CAS: | 591-22-0 | | MF: | C7H9N | | MW: | 107.15 | | EINECS: | 209-708-6 | | Product Categories: | Biochemistry;Reagents for Oligosaccharide Synthesis;Pyridines derivates;Heterocyclic Compounds;K00001 | | Mol File: | 591-22-0.mol |  |
| | 3,5-Lutidine Chemical Properties |
| Melting point | -9 °C (lit.) | | Boiling point | 169-170 °C (lit.) | | density | 0.939 g/mL at 25 °C (lit.) | | vapor pressure | 1.5 mm Hg ( 20 °C) | | refractive index | n20/D 1.504(lit.) | | Fp | 128 °F | | storage temp. | 2-8°C | | form | Liquid | | pka | 6.15(at 25℃) | | color | Clear yellow | | Water Solubility | 33 g/L (20 ºC) | | Specific Heat Capacity | Cp(liquid): 1.72 J/(g·K), at 25℃ | | Sensitive | Hygroscopic | | BRN | 105682 | | Henry's Law Constant | 1.4×100 mol/(m3Pa) at 25℃, Andon et al. (1954) | | InChI | 1S/C7H9N/c1-6-3-7(2)5-8-4-6/h3-5H,1-2H3 | | InChIKey | HWWYDZCSSYKIAD-UHFFFAOYSA-N | | SMILES | Cc1cncc(C)c1 | | LogP | 1.780 | | CAS DataBase Reference | 591-22-0(CAS DataBase Reference) | | NIST Chemistry Reference | Pyridine, 3,5-dimethyl-(591-22-0) | | EPA Substance Registry System | 3,5-Dimethylpyridine (591-22-0) |
| Hazard Codes | Xn,F,Xi,T | | Risk Statements | 10-20/21/22-36/37/38-41-34-23/25-21 | | Safety Statements | 16-26-36-36/37-45-36/37/39 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | F | 8 | | Hazard Note | Irritant/Flammable | | TSCA | TSCA listed | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29333999 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1B |
| | 3,5-Lutidine Usage And Synthesis |
| Chemical Properties | CLEAR YELLOW LIQUID | | Uses | 3,5-Lutidine is a reactant used in the synthesis of phthalazine and pyrazine compounds, as well as other pharmaceuticals. | | Synthesis Reference(s) | Synthesis, p. 573, 1994 DOI: 10.1055/s-1994-25526 | | Flammability and Explosibility | Flammable | | Purification Methods | Dry 3,5-lutidine with sodium and fractionally distil it through a Todd column (p 11) packed with glass helices. Dissolve (100mL) in dilute HCl (1:4) and steam distil this until 1L of distillate is collected. Excess conc NaOH is added to the residue which is again steam distilled. The base is extracted from the distillate, using diethyl ether. The extract is dried over K2CO3, and distilled. It is then fractionally crystallised by partial freezing. The hydrochloride has m 229o(sublimes at 190-231o), and the picrate has m 242-243o(dec, from H2O), 249-250o(dec, from AcOH). [Beilstein 20 II 161, 20 III/IV 2788, 20/6 V 60.] | | Toxics Screening Level | The initial threshold screening level (ITSL) for 3,5-lutidine is 0.1 μg/m3 (annual averaging time). |
| | 3,5-Lutidine Preparation Products And Raw materials |
| Raw materials | Methyl vinyl sulfone | | Preparation Products | 5-Methylpyridin-3-amine-->3,5-DIMETHYLPYRIDIN-4-AMINE-->3,5-bis(chloromethyl)pyridine-->ETHYL METHYLPHOSPHONIC ACID-->3-CYANO-5-METHYLPYRIDINE-->METHYL 5-METHYLNICOTINATE-->2,3,5-Collidine-->1,3,5-Trimethyl-1,2-dihydropyridin-2-one-->1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-(1,1-diMethylethyl)-5-Methyl--->3,5-Dimethylpiperidine-->3,5-dimethylpyridine-4-carboxylic acid |
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