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p-Hydroxymethamphetamine

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p-Hydroxymethamphetamine Basic information
Product Name:p-Hydroxymethamphetamine
Synonyms:1-(p-hydroxyphenyl)-2-methylaminopropane;1-(p-oxyphenyl)-2-methylaminopropan;alpha-(p-hydroxyphenyl)-beta-methylaminopropane;alpha-(p-oxyphenyl)-beta-methylaminopropane;beta-(p-hydroxyphenyl)isopropylmethylamine;beta(p-oxy-phenyl)isopropylmethylamin;epifen;foledrin
CAS:370-14-9
MF:C10H15NO
MW:165.23
EINECS:206-725-0
Product Categories:Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:370-14-9.mol
p-Hydroxymethamphetamine Structure
p-Hydroxymethamphetamine Chemical Properties
Melting point 162-163°
Boiling point 293.09°C (rough estimate)
density 1.0203 (rough estimate)
refractive index 1.4820 (estimate)
storage temp. −20°C
solubility Methanol (Slightly)
pka9.82±0.15(Predicted)
Major Applicationforensics and toxicology
pharmaceutical (small molecule)
veterinary
InChI1S/C10H15NO/c1-8(11-2)7-9-3-5-10(12)6-4-9/h3-6,8,11-12H,7H2,1-2H3
InChIKeySBUQZKJEOOQSBV-UHFFFAOYSA-N
SMILESCNC(C)Cc1ccc(O)cc1
Safety Information
Hazard Codes Xi,T,F
Risk Statements 36/37/38-39/23/24/25-23/24/25-11
Safety Statements 26-36-45-36/37-16-7
WGK Germany 3
RTECS SL8400000
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
ToxicityLD50 parenteral in mouse: 100mg/kg
MSDS Information
p-Hydroxymethamphetamine Usage And Synthesis
Chemical PropertiesOff-White Solid
OriginatorPholedrine Sulfate, ZYF Pharm Chemical
UsesAn a-adrenergic agonist. Antihypotensive.
DefinitionChEBI: Pholedrine is a member of amphetamines.
Manufacturing Process100 g β-(methoxyphenyl)isopropylamine prepared, for example by reduction of p-methoxybenzylmethylketone with hydrogen and nickel catalyst in presence of ammonia or by Mannix's method, 250 ml ethanol and calculated quantity of solution of formaldehyde and 70 g activated aluminum shaving were heated for 6 hours by stirring. The mixture was filtered, the solvent was removed in vacuum and the residue was dissolved in ethanol contained hydrochloric acid. The prepared hydrochloride of β-(pmethoxyphenyl)isopropylmethylamine had MP: 174°C.
In practice it is usually used as sulfate.
Therapeutic FunctionSympathomimetic, Mydriatic, Analeptic, Vasopressor
Biological ActivityA metabolite of methamphetamine; sympathomimetic
p-Hydroxymethamphetamine Preparation Products And Raw materials
Raw materialsHydrogen-->4-Methoxyphenylacetone-->Nickel
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