- 3,5-Dimethylphenylboronic acid
-
- $34.00 / 1kg
-
2025-09-25
- CAS:172975-69-8
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
|
| | 3,5-Dimethylphenylboronic acid Basic information |
| | 3,5-Dimethylphenylboronic acid Chemical Properties |
| Melting point | 261-265 °C (lit.) | | Boiling point | 312.7±52.0 °C(Predicted) | | density | 1.07±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | Water Solubility | Slightly soluble in water | | form | solid | | pka | 8.72±0.10(Predicted) | | color | White to Orange to Green | | BRN | 7368658 | | InChI | InChI=1S/C8H11BO2/c1-6-3-7(2)5-8(4-6)9(10)11/h3-5,10-11H,1-2H3 | | InChIKey | DJGHSJBYKIQHIK-UHFFFAOYSA-N | | SMILES | B(C1=CC(C)=CC(C)=C1)(O)O | | CAS DataBase Reference | 172975-69-8(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 37/39-26-36/37 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29319090 | | Storage Class | 11 - Combustible Solids |
| | 3,5-Dimethylphenylboronic acid Usage And Synthesis |
| Chemical Properties | off-white to light yellow crystalline powder | | Uses | suzuki reaction | | Uses | 3,5-Dimethylphenylboronic Acid is a useful research intermediate for organic synthesis | | Uses | 3,5-Dimethylphenylboronic acid (DMPBA) can be used as:
- A reactant in the palladium-catalyzed Suzuki coupling reactions.
- A co-extractant in the combination with modified Aliquat 336 for the extraction of xylose, glucose, and fructose from aqueous solutions.
- A reactant to prepare penultimate methyl ester.
| | Synthesis | GENERAL PROCEDURE: A 1 M THF solution (375 μL, 375 μmol) of phenylmagnesium bromide (PhMgBr) was added dropwise to a tetrahydrofuran (THF, 4 mL) solution of diisopropylaminoborane (DIPAB, 863 mg, 7.5 mmol) and magnesium scrapings (Mg, 182 mg, 7.5 mmol) at room temperature. After 10 min of reaction, 30 mL of anhydrous THF was added, followed by 3,5-dimethylbromobenzene (5 mmol). The reaction mixture was cooled to 0 °C and quenched by slow addition of methanol (MeOH, 7 mL). After 1 h of reaction, the volatiles were removed under reduced pressure and the resulting solid was dissolved in a 1N hydrochloric acid/methanol (7:3, v/v) mixture. The reaction was continued for 1 h at room temperature, followed by the addition of ethyl acetate (AcOEt, 100 mL) for extraction. The organic phase was washed sequentially with 1N hydrochloric acid (30 mL) and saturated saline (3 x 30 mL). The organic phase was concentrated under reduced pressure to give the crude product, which was finally purified by recrystallization from water (H2O) to give 3,5-dimethylphenylboronic acid. | | References | [1] Tetrahedron, 2019, vol. 75, # 2, p. 164 - 171 |
| | 3,5-Dimethylphenylboronic acid Preparation Products And Raw materials |
|