- 6-Bromohexanoic acid
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- $1.00
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2026-09-11
- CAS:4224-70-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1000kg/month
- 6-Bromohexanoic acid
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- $30.00
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2026-08-07
- CAS:4224-70-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200000KG
Related articles - Preparation of 6-Bromocaproic Acid
- 6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely....
- Dec 20，2019
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| | 6-Bromohexanoic acid Chemical Properties |
| Melting point | 32-34 °C (lit.) | | Boiling point | 165-170 °C/20 mmHg (lit.) | | density | 1.3996 (rough estimate) | | refractive index | 1.4790 (estimate) | | Fp | 154 °F | | storage temp. | Inert atmosphere,2-8°C | | solubility | methanol: 0.1 g/mL, clear, colorless | | pka | 4.72±0.10(Predicted) | | form | Low Melting Crystals | | color | White to light orange | | BRN | 1749740 | | InChI | 1S/C6H11BrO2/c7-5-3-1-2-4-6(8)9/h1-5H2,(H,8,9) | | InChIKey | NVRVNSHHLPQGCU-UHFFFAOYSA-N | | SMILES | OC(=O)CCCCCBr | | LogP | 1.700 (est) | | CAS DataBase Reference | 4224-70-8(CAS DataBase Reference) | | NIST Chemistry Reference | Hexanoic acid, 6-bromo-(4224-70-8) | | EPA Substance Registry System | Hexanoic acid, 6-bromo- (4224-70-8) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-36/37/39-45-28A | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | F | 8 | | Hazard Note | Corrosive/Harmful | | TSCA | TSCA listed | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29159080 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Skin Corr. 1B |
| | 6-Bromohexanoic acid Usage And Synthesis |
| Organic Intermediate | 6-bromohexanoic acid(CAS:4224-70-8), also called 6-bromohexanoic acid or 6-bromo-hexanoic acid, is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. 6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely used as an intermediate in organic synthesis. Here, we introduced a method for making this compound. | | Chemical Properties | White to light orange low melting crystals | | Uses | Employed in a direct preparation of N-acylsulfonamides on treatment with tosyl isocyanate (189278)1 and alkyl ketones from alkyl iodides and metallic strontium.2 | | Uses | 6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely used as an intermediate in organic synthesis. | | Uses | 6-Bromohexanoic acid was used in the preparation of N-acylsulfonamides on treatment with tosyl isocyanate (189278) and alkyl ketones from alkyl iodides and metallic strontium. It was also used in the synthesis of anionic mitomycin C-dextran conjugate (MMC-D), 2-lithio-1,3-dithian and diaryl thioethers. | | Definition | ChEBI: 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It is functionally related to a hexanoic acid. | | Synthesis Reference(s) | Journal of the American Chemical Society, 72, p. 5137, 1950 DOI: 10.1021/ja01167a091 | | Synthesis | The preparation method of the high purity 6-bromocaproic acid: the exsiccant bromize hydrogen gas is directly fed contain in the organic solvent of 6-caprolactone, exsiccant bromize hydrogen gas usage quantity is 6-caprolactone 1.0-2.0 doubly (mol ratio); Stir, ring-opening reaction takes place, temperature of reaction is 0 ℃ ~ 100 ℃, generates high purity 6-bromocaproic acid. | | References | [1] Reactive and Functional Polymers, 2016, vol. 99, p. 1 - 8
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 1, p. 567 - 579
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 9, p. 2896 - 2903
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 23, p. 7681 - 7687
[5] Journal of the American Chemical Society, 1982, vol. 104, # 5, p. 1391 - 1403 |
| | 6-Bromohexanoic acid Preparation Products And Raw materials |
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