- C646
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- $41.00 / 2mg
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2026-05-14
- CAS:328968-36-1
- Min. Order:
- Purity: 99.00%
- Supply Ability: 10g
- C 646
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- $15.00 / 1KG
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2021-07-13
- CAS:328968-36-1
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- C 646
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- $15.00 / 1KG
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2021-07-09
- CAS:328968-36-1
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| Product Name: | C 646 | | Synonyms: | C 646;(E)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid;(Z)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid;4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid;Benzoic acid, 4-[4-[[5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-;4-[(4Z)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid;104475;CS-1006 | | CAS: | 328968-36-1 | | MF: | C24H19N3O6 | | MW: | 445.42 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 328968-36-1.mol |  |
| | C 646 Chemical Properties |
| Melting point | 224-226℃ | | Boiling point | 662.6±65.0 °C(Predicted) | | density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >25mg/mL | | form | powder | | pka | 4.20±0.10(Predicted) | | color | red to brown | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. | | InChI | 1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12- | | InChIKey | HEKJYZZSCQBJGB-XDHOZWIPSA-N | | SMILES | Cc1cc(-c2ccc(\C=C3\C(C)=NN(c4ccc(cc4)C(O)=O)C3=O)o2)c(cc1C)[N+]([O-])=O |
| Hazard Codes | N | | Risk Statements | 50 | | Safety Statements | 61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | C 646 Usage And Synthesis |
| Description | C-646 (328968-36-1) is a potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. C-646 enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable. | | Uses | C646 is an inhibitor for histone acetyltransferase p300 and may be a potential candidate for treating AML1-ETO (AE) positive acute myeloid leukemia (AML). It is shown that C646 inhibited cellular proliferation, reduced colony formation, evoked partial cell cycle arrest in the G1 phase, and induced apoptosis in AE-positive AML cell lines and primary blasts isolated from leukemic mice and AML patients. | | Uses | C646 was used to study the role of p300 in chronic neuropathic pain in rats with chronic constriction injury. | | Definition | ChEBI: A pyrazolone that is 5-methyl-4-methylene-2-(p-carboxyphenyl)-2,4-dihydro-3H-pyrazol-3-one in which the exocyclic carbon of the methylene group is attached to a 5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl group by a single bond
C646 is a potent, cell permeable and selective competitive inhibitor of p300 and CBP (p300/CBP) histone acetyltransferases. | | Biochem/physiol Actions | C646 is a potent, cell permeable and selective inhibitor of p300 and CBP (p300/CBP) histone acetyltransferases. Inhibition of p300/CBP by C646 affects the activity of a variety of transcriptional factors such as NF-κB, p53 and MyoD that are associated with physiology, disease processes, hippocampal synaptic plasticity, spatial memory and contextual fear. | | storage | Store at +4°C | | References | [1] ERIN M BOWERS. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.[J]. Chemistry & biology, 2010, 17 5: 471-482. DOI:10.1016/j.chembiol.2010.03.006
[2] FRÉDÉRIC R SANTER. Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines.[J]. Molecular Cancer Therapeutics, 2011, 10 9: 1644-1655. DOI:10.1158/1535-7163.mct-11-0182
[3] ROGER MAREK. Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300.[J]. Journal of Neuroscience, 2011, 31 20: 7486-7491. DOI:10.1523/jneurosci.0133-11.2011
[4] SANG-WON MIN. Acetylation of tau inhibits its degradation and contributes to tauopathy.[J]. Neuron, 2010, 67 6: 953-966. DOI:10.1016/j.neuron.2010.08.044 |
| | C 646 Preparation Products And Raw materials |
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