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| | Propargyl-PEG4-CH2CO2tBu Basic information |
| Product Name: | Propargyl-PEG4-CH2CO2tBu | | Synonyms: | Propargyl-PEG4-CH2CO2tBu;Alkyne-PEG4-CH2COOtBu;PROPARGYL-PEG4-CH2COOTBU;tert-butyl-2-(2-{2-[2-(prop-2-ynyloxy)ethoxy]ethoxy}ethoxy)acetate;Propargyl-PEG3-t-butyl acetate;Propargyl-PEG3-CH2COOtBu;Propargyl-PEG3-OCH2-Boc;tert-butyl 3,6,9,12-tetraoxapentadec-14-ynoate | | CAS: | 888010-02-4 | | MF: | C15H26O6 | | MW: | 302.36 | | EINECS: | | | Product Categories: | peg | | Mol File: | 888010-02-4.mol |  |
| | Propargyl-PEG4-CH2CO2tBu Chemical Properties |
| Boiling point | 365.6±32.0 °C(Predicted) | | density | 1.046±0.06 g/cm3(Predicted) |
| | Propargyl-PEG4-CH2CO2tBu Usage And Synthesis |
| Description | Propargyl-PEG4-CH2CO2tBu is a PEG reagent that can reacts with azide compounds or biomolecules under the catalyzation of copper. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | Propargyl-PEG3-OCH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-OCH2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Propargyl-PEG4-CH2CO2tBu Preparation Products And Raw materials |
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