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| | Propargyl-PEG5-beta-D-galactose Basic information |
| Product Name: | Propargyl-PEG5-beta-D-galactose | | Synonyms: | Propargyl-PEG5-beta-D-galactose;Propargyl-PEG5-beta-D-glucose;Propargyl-PEG4-beta-D-glucose;β-D-Galactopyranoside, 3,6,9,12-tetraoxapentadec-14-yn-1-yl;(2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]tetrahydropyran-3,4,5-triol;Propargyl-PEG4-beta-D-glucose95;β-Gal-PEG4-Alkyne | | CAS: | 1397682-63-1 | | MF: | C17H30O10 | | MW: | 394.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1397682-63-1.mol |  |
| | Propargyl-PEG5-beta-D-galactose Chemical Properties |
| Boiling point | 578.6±50.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | pka | 12.90±0.70(Predicted) |
| | Propargyl-PEG5-beta-D-galactose Usage And Synthesis |
| Description | Propargyl-PEG5-beta-D-glucose is a Click Chemistry-ready crosslinker containing a propargyl group and beta-D-glucose. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. D-glucose increases solubility in aqueous media and increases the selectivity of the PEGylation reaction. | | Uses | Propargyl-PEG4-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Propargyl-PEG5-beta-D-galactose Preparation Products And Raw materials |
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