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| | Propargyl-PEG4-CH2CO2-NHS Basic information |
| Product Name: | Propargyl-PEG4-CH2CO2-NHS | | Synonyms: | Propargyl-PEG4-CH2CO2-NHS;3,6,9,12-Tetraoxapentadec-14-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester;Propargyl-PEG3-CH2COONHS;Propargyl-PEG4-CH2COO-NHS ester;Propargyl-PEG4-CH2COOH NHS Ester;2,5-dioxopyrrolidin-1-yl 3,6,9,12-tetraoxapentadec-14-ynoate;Propargyl-PEG3-CH2CONHS ester;Propargyl-PEG3-O-CH2-NHS ester | | CAS: | 2144777-76-2 | | MF: | C15H21NO8 | | MW: | 343.33 | | EINECS: | | | Product Categories: | | | Mol File: | 2144777-76-2.mol |  |
| | Propargyl-PEG4-CH2CO2-NHS Chemical Properties |
| solubility | Soluble in DMSO, DCM, DMF |
| | Propargyl-PEG4-CH2CO2-NHS Usage And Synthesis |
| Description | Propargyl-PEG4-CH2CO2-NHS has a propargyl group and an NHS group. This reagent is amine reactive, thus, useful for derivatizing biomolecules with amine group. The propargyl group reacts with azides via copper catalyzed azide-alkyne Click Chemistry to form stable triazole bond. | | Uses | Propargyl-PEG4-CH2CO2-NHS (compound P-7) is a PEG derivative containing a propargyl group and an NHS group. Propargyl-PEG4-CH2CO2-NHS is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG4-CH2CO2-NHS is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1]. | | References | [1] Woo Sung-ho, et al. Composé comprenant un groupe auto-immolable et conjugué ligand-médicament le comprenant. WO2024005460A1. |
| | Propargyl-PEG4-CH2CO2-NHS Preparation Products And Raw materials |
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