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| | 2-Amino-3-methylphenol Basic information |
| | 2-Amino-3-methylphenol Chemical Properties |
| Melting point | 149-152 °C (lit.) | | Boiling point | 229.26°C (rough estimate) | | density | 1.0877 (rough estimate) | | refractive index | 1.5706 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 9.87±0.10(Predicted) | | form | powder to crystalline | | color | White to Brown | | InChI | 1S/C7H9NO/c1-5-3-2-4-6(9)7(5)8/h2-4,9H,8H2,1H3 | | InChIKey | FEDLEBCVFZMHBP-UHFFFAOYSA-N | | SMILES | Cc1cccc(O)c1N | | CAS DataBase Reference | 2835-97-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | HS Code | 29222990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Amino-3-methylphenol Usage And Synthesis |
| Chemical Properties | Light yellow solid | | Uses | 2-Amino-3-methylphenol was used in the preparation of Schiff base ligands. | | General Description | 2-Amino-3-methylphenol is an aminophenol formed by incubating isopropyl-β-D-thiogalactopyranoside-induced E. coli JS996 strain cells with various nitroaromatic compounds. | | Synthesis | The general procedure for the synthesis of 2-amino-3-methylphenol from 2-nitro-3-methylphenol was as follows: 3-methyl-2-nitrophenol (1.0 g, 6.53 mmol) was dissolved in methanol (10 mL) at 23 °C, and Pd/C catalyst (10 wt%, 400 mg) was added. The reaction mixture was deoxygenated under vacuum and then hydrogenated with a hydrogen balloon. After the reaction was carried out under stirring for 5 h, the reaction mixture was filtered through a diatomaceous earth pad and the diatomaceous earth pad was washed with methanol (100 mL). The combined filtrates were concentrated under vacuum to afford the target product 2-amino-3-methylphenol (803 mg, 100% yield). | | References | [1] Patent: US2006/211603, 2006, A1. Location in patent: Page/Page column 68
[2] Patent: EP1346982, 2003, A1
[3] Journal of the Chemical Society, 1925, vol. 127, p. 498
[4] Chemische Berichte, 1961, vol. 94, p. 2551 - 2561
[5] Journal of Organic Chemistry, 1989, vol. 54, # 15, p. 3740 - 3744 |
| | 2-Amino-3-methylphenol Preparation Products And Raw materials |
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