Irofulven manufacturers
- Irofulven
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- $1.00
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2026-09-11
- CAS:920014-72-8
- Purity: 99%
- Supply Ability: 50kg
- Setmelanotide
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- $2.00
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2026-08-25
- CAS:920014-72-8
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
- Setmelanotide
-
- $75.00
-
2026-08-25
- CAS:920014-72-8
- Min. Order: 10kg
- Purity: 0.99
- Supply Ability: 20tons
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| | Irofulven Basic information |
| Product Name: | Irofulven | | Synonyms: | BIM-22493;IRC-022493);RM-493;RM-493; BIM-22493; IRC-022493);Ac-Arg-c(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2;L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2→8)-disulfide;Setmelanotide (RM-493) trifluoroacetate salt;Setmelanotide (RM-493) | | CAS: | 920014-72-8 | | MF: | C49H68N18O9S2 | | MW: | 1117.31 | | EINECS: | 000-000-0 | | Product Categories: | | | Mol File: | 920014-72-8.mol |  |
| | Irofulven Chemical Properties |
| density | 1.54±0.1 g/cm3(Predicted) | | pka | 12.82±0.70(Predicted) | | form | Solid | | color | White to off-white | | Sequence | Ac-Arg-Cys-D-Ala-His-D-Phe-Arg-Trp-Cys-NH2(Disulfide bond) | | InChIKey | HDHDTKMUACZDAA-JFHGRQLZNA-N |
| | Irofulven Usage And Synthesis |
| Uses | Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively[1]. | | in vivo | Inhibition of refeeding after an overnight fast by Setmelanotide is dependent on functional MC4R, and does not require MC3R. BIM-22493 acutely improves glucose homeostasis. Lepob/Lepob mice treated with BIM-22493 exhibits significantly improved glucose clearance when compared to controls. Chronic BIM-22493 treatment was associated with significantly lower levels of serum glucose and HOMA-IR values[1].
Treatment with setmelanotide results in transient decreases in food intake (35%), with persistent weight loss over 8 weeks of treatment (13.5%) in a diet-induced obese nonhuman primate model[2]. | | References | [1] Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30(10):1892-900. DOI:10.1016/j.peptides.2009.07.012
[2] Kievit P, et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes. 2013 Feb;62(2):490-7. DOI:10.2337/db12-0598 |
| | Irofulven Preparation Products And Raw materials |
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