E3 Ligand-Linker Conjugate 7 manufacturers
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| | E3 Ligand-Linker Conjugate 7 Basic information |
| Product Name: | E3 Ligand-Linker Conjugate 7 | | Synonyms: | E3 Ligand-Linker Conjugate 7;N-(2-(2-Aminoethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide;Thalidomide-O-amido-PEG-C2-NH2;Acetamide, N-[2-(2-aminoethoxy)ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-;N-[2-(2-Aminoethoxy)ethyl]-2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]oxy]acetamide;N-[2-(2-Aminoethoxy)ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide | | CAS: | 2022182-59-6 | | MF: | C19H22N4O7 | | MW: | 418.4 | | EINECS: | | | Product Categories: | | | Mol File: | 2022182-59-6.mol |  |
| | E3 Ligand-Linker Conjugate 7 Chemical Properties |
| Boiling point | 766.2±60.0 °C(Predicted) | | density | 1.422±0.06 g/cm3(Predicted) | | pka | 10.68±0.40(Predicted) |
| | E3 Ligand-Linker Conjugate 7 Usage And Synthesis |
| Description | N-(2-(2-Aminoethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide is an E3 ligase ligand-linker conjugate used in PROTAC dTAG-13 as a degrader of FKBP12 F36V and BET. | | Uses | Thalidomide-O-amido-PEG-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | | IC 50 | Cereblon | | References | [1] Chessum NEA, et al. Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766). J Med Chem. 2018 Feb 8;61(3):918-933. DOI:10.1021/acs.jmedchem.7b01406
[2] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[3] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | E3 Ligand-Linker Conjugate 7 Preparation Products And Raw materials |
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