N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide manufacturers
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| | N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide Basic information |
| Product Name: | N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide | | Synonyms: | N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide;E3 ligase Ligand-Linker Conjugates 18;Azido-Thalidomide;N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide;Cereblon Ligand-Linker Conjugates 4;Thalidomide O amido C4 N3,ThalidomideOamidoC4N3,Inhibitor,inhibit,Thalidomide-O-amido-C-4-N3,E3 Ligase Ligand-Linker Conjugates;Thalidomide 4'-oxyacetamide-alkylC4-azide;Acetamide, N-(4-azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- | | CAS: | 2098488-36-7 | | MF: | C19H20N6O6 | | MW: | 428.3987 | | EINECS: | | | Product Categories: | | | Mol File: | 2098488-36-7.mol |  |
| | N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide Chemical Properties |
| solubility | DMF: 12 mg/ml; DMSO: 12 mg/ml; DMSO:PBS (pH 7.2)(1:8): 0.11 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide Usage And Synthesis |
| Description | UUN 88367, also known as Azido-Thalidomide is a clickable Thalidomide derivative, used as a building block for cereblon. Azido-Thalidomide targets PROTACs by hijacking cereblon as the E3 ubiquitin ligase component. This product has no formal name at the moment. | | Uses | Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | Cereblon | | storage | Store at -20°C | | References | [1] Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491. DOI:10.1021/acs.jmedchem.6b01872 |
| | N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide Preparation Products And Raw materials |
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