|
|
| Product Name: | FITONE | | Synonyms: | perhydrofarnesylacetone,6,10,14-trimethyl-2-pentadecanone;6,10,14-TRIMEHJTYLPENTADECA-2-ONE;Fitone, Hexahydrofarnezylacetone;2,6,10-trimethyl-14-pentadecanone;SALOR-INT L299286-1EA;FITONE;HEXAHYDROFARNEZYLACETON;2-pentadecanone,6,10,14-trimethyl | | CAS: | 502-69-2 | | MF: | C18H36O | | MW: | 268.48 | | EINECS: | 207-950-7 | | Product Categories: | Pharmaceutical Intermediates | | Mol File: | 502-69-2.mol |  |
| | FITONE Chemical Properties |
| Melting point | 129-136 °C | | Boiling point | 142-143 °C(Press: 3 Torr) | | density | 0.8403 g/cm3(Temp: 19 °C) | | storage temp. | Store at -20°C | | solubility | DMSO: 100 mg/mL (372.47 mM) | | form | Oil | | color | Colorless to light yellow | | Odor | at 100.00 %. oily herbal jasmin celery woody | | Odor Type | floral | | LogP | 7.133 (est) | | EPA Substance Registry System | 2-Pentadecanone, 6,10,14-trimethyl- (502-69-2) |
| Hazard Codes | Xi | | TSCA | TSCA listed | | HS Code | 2914199090 |
| | FITONE Usage And Synthesis |
| Uses | FITONE is used as a flavor and fragrance agent, it is often used in jasmine compositions. | | Definition | ChEBI: Hexahydrofarnesyl acetone is a ketone. | | in vivo | The essential oil of Albizia zygia (containing 33.14% Hexahydrofarnesyl acetone, 100, 200, 400 mg/kg, p.o., single dose) inhibits carrageenan (HY-125474)-induced inflammation in the paw edema model of Wistar rats[1].
The essential oil of Albizia zygia (containing 33.14% Hexahydrofarnesyl acetone, 100, 200, 400 mg/kg, p.o., single dose) exhibits analgesic effects in the formalin-induced pain model in Wistar rats[1]. | Animal Model: | Carrageenan (HY-125474)-induced paw edema model in Wistar rats (150-200 g)[1] | | Dosage: | 100, 200, 400 mg/kg | | Administration: | Oral gavage (p.o.), single dose | | Result: | Exerted a significant dose-dependent inhibitory effect on the development of carrageenan (HY-125474)-induced paw swelling. |
| Animal Model: | Formalin-induced pain model in Wistar rats (150-200 g)[1] | | Dosage: | 100, 200, 400 mg/kg | | Administration: | Oral gavage (p.o.), single dose | | Result: | Increased the tolerance of rats to Formalin-induced pain. |
|
| | FITONE Preparation Products And Raw materials |
| Raw materials | 3,7,11,15-tetramethylhexadec-1-yn-3-ol-->(+)-Phytone-->3,7,11,15-TETRAMETHYL-2-HEXADECEN-1-OL-->Teprenone Impurity 3-->Farnesylacetone-->(5E,9E)-6,10,14-Trimethylpentadeca-5,9,13-trien-2-one-->(E)-BETA-FARNESENE-->Isophytol-->3-Methyl butynol | | Preparation Products | 2,6,10-TRIMETHYLPENTADECANE |
|