- 2-Phenylpiperazine
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- $1.10 / 1g
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2025-11-18
- CAS:5271-26-1
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons
- 2-Phenylpiperazine
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- $0.00 / 1KG
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2019-07-07
- CAS: 5271-26-1
- Min. Order: 1KG
- Purity: 90%-99.9%
- Supply Ability: 500kg
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| | 2-Phenylpiperazine Basic information |
| | 2-Phenylpiperazine Chemical Properties |
| Melting point | 83-87 °C (lit.) | | Boiling point | 138 °C | | density | 0.997±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | solid | | pka | 8.80±0.40(Predicted) | | color | Yellow | | InChI | 1S/C10H14N2/c1-2-4-9(5-3-1)10-8-11-6-7-12-10/h1-5,10-12H,6-8H2 | | InChIKey | RIMRLBGNCLMSNH-UHFFFAOYSA-N | | SMILES | C1CNC(CN1)c2ccccc2 | | CAS DataBase Reference | 5271-26-1(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36/37 | | RIDADR | UN3259 | | WGK Germany | 2 | | Hazard Note | Irritant | | HazardClass | 8 | | HS Code | 29335990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Phenylpiperazine Usage And Synthesis |
| Uses | 2-Phenylpiperazine is the starting material for the synthesis of 2-phenylpiperazine compounds. It has been synthesized 1,4-dimethyl-2-phenylpiperazine, 1,4-diethyl-2-phenyl Piperazine etc. | | Synthesis | General procedure for the synthesis of 2-phenylpiperazine from 3-oxo-2-phenylpiperazine: 2-oxo-3-phenylpiperazine (1.76 g, 10 mmol) was dissolved in 30 mL of anhydrous THF and added slowly and dropwise to 20 mL (20 mmol) of a THF solution of 1M LiAlH4. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, water and 20% NaOH solution were carefully added to quench the excess LiAlH4. Subsequently, the reaction mixture was filtered and the filter cake was re-extracted with ethyl acetate. The organic filtrate and extract were combined, dried with MgSO4, filtered and concentrated under reduced pressure to give a light yellow solid. The crude product was further purified by silica gel column chromatography (eluent: CHCl3:MeOH:NH4OH = 9:1:0.1) to afford 2-phenylpiperazine (960 mg, 6 mmol, 60% yield) as a colorless solid. The product was characterized by 1H NMR (CDCl3): δ 2.69 (1H, t, J = 11.3 Hz), 2.85-3.10 (7H, m), 3.76 (1H, br d, J = 8.9 Hz), 7.21-7.38 (5H, m). Melting point determination (capillary method): 79-81°C. | | References | [1] Patent: WO2004/63150, 2004, A2. Location in patent: Page 28-29
[2] Patent: US2005/222166, 2005, A1. Location in patent: Page/Page column 13
[3] Patent: EP1396487, 2004, A1. Location in patent: Page 17-18 |
| | 2-Phenylpiperazine Preparation Products And Raw materials |
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