2-Amino-3-bromo-5-nitropyridine

2-Amino-3-bromo-5-nitropyridine Suppliers list

Company Name:	Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:	4006356688 18621169109
Email:	market03@meryer.com

Company Name:	Liaoning Tianhua Chemical Co., Ltd.
Tel:	0418-6530555 2855550
Email:

2-Amino-3-bromo-5-nitropyridine manufacturers

2-Amino-3-bromo-5-nitropyridine Basic information

Product Name:	2-Amino-3-bromo-5-nitropyridine
Synonyms:	AURORA KA-367;2-Amino-3-bromo-5-nitropyridine 98%;2-PYRIDINAMINE, 3-BROMO-5-NITRO-;2-AMINO-3-BROMO-5-NITROPYRIDINE;2-Amino-3-bromo-5-nitropyridine,98%;2-AMino-3-broMo-5-nitropyridine, 98% 1GR;3-Bromo-5-nitro-pyridin-2-ylamine;2-Amino-3-bromo-5-nitropyridine ISO 9001：2015 REACH
CAS:	15862-31-4
MF:	C5H4BrN3O2
MW:	218.01
EINECS:	689-323-1
Product Categories:	amine\| alkyl bromide\| nitro-compound;Boronic Acid;Amino-pyridine series;Amines;blocks;Bromides;Pyridines;Pyridine
Mol File:	15862-31-4.mol

2-Amino-3-bromo-5-nitropyridine Chemical Properties

Melting point	215-219 °C
Boiling point	347.3±37.0 °C(Predicted)
density	1.9128 (rough estimate)
refractive index	1.6200 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	0.06±0.49(Predicted)
form	Powder
color	Beige to orange-brown
InChI	InChI=1S/C5H4BrN3O2/c6-4-1-3(9(10)11)2-8-5(4)7/h1-2H,(H2,7,8)
InChIKey	OFXNHXMPRZDIDM-UHFFFAOYSA-N
SMILES	C1(N)=NC=C([N+]([O-])=O)C=C1Br
CAS DataBase Reference	15862-31-4(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
ACROS	English

2-Amino-3-bromo-5-nitropyridine Usage And Synthesis

Chemical Properties	Beige to orange-brown powder
Uses	2-Amino-3-bromo-5-nitropyridine is a useful intermediate for organic synthesis.
Synthesis	4214-76-0 15862-31-4 Step a: Bromine (38 g, 0.24 mol) was slowly added dropwise to a solution of 2-amino-5-nitropyridine (30 g, 0.22 mol) in acetic acid (200 mL) at 10 °C. After the dropwise addition was completed, the reaction mixture was warmed to 20 °C and stirring was continued for 30 min. Upon completion of the reaction, the solid product was collected by filtration and dissolved in ethyl acetate (200 mL). The pH of the mixture was adjusted to 8-9 with saturated aqueous sodium bicarbonate. the organic layer was separated and the aqueous layer was extracted with ethyl acetate (100 mL x 3). The organic layers were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 2-amino-3-bromo-5-nitropyridine (14.8 g, 32% yield). The product was characterized by 1H-NMR (CDCl3,400MHz): δ 8.94 (d, J=2.4Hz, 1H), 8.50 (d, J=2.4Hz, 1H), 5.67 (brs, 2H).
References	[1] Patent: US2009/253736, 2009, A1. Location in patent: Page/Page column 25 [2] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 14, p. 3853 - 3860 [3] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1920, vol. 50, p. 494 [4] Chem. Zentralbl., 1923, vol. 94, # III, p. 1021 [5] Zhurnal Obshchei Khimii, 1940, vol. 10, p. 1827,1836

2-Amino-3-bromo-5-nitropyridine Preparation Products And Raw materials

Raw materials

Tag:2-Amino-3-bromo-5-nitropyridine(15862-31-4) Related Product Information

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