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| | Norfenfluramine Basic information |
| Product Name: | Norfenfluramine | | Synonyms: | 1-[3-(Trifluoromethyl)phenyl]-2-aminopropane;α-Methyl-m-(trifluoromethyl)phenethylamine;[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amine;Norfenfluramine (racemate);5-HTT,inhibit,antiepileptic,Norfenfluramine,Fenfluramine,transporter,Serotonin Transporter,5-HT,SLC6A4,SERT,Inhibitor;Benzeneethanamine, α-methyl-3-(trifluoromethyl)-;1-[3-(Trifluoromethyl)phenyl]-2-propanamine | | CAS: | 1886-26-6 | | MF: | C10H12F3N | | MW: | 203.2 | | EINECS: | | | Product Categories: | | | Mol File: | 1886-26-6.mol |  |
| | Norfenfluramine Chemical Properties |
| Boiling point | 96 °C(Press: 17 Torr) | | density | 1.152±0.06 g/cm3(Predicted) | | pka | 9.77±0.10(Predicted) |
| Toxicity | LD50 intraperitoneal in mouse: 51mg/kg |
| | Norfenfluramine Usage And Synthesis |
| Uses | Norfenfluramine ((±)-Norfenfluramine) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine displays antiepileptic effects in vivo[1][2]. | | Definition | ChEBI: 1-[3-(trifluoromethyl)phenyl]-2-propanamine is a member of amphetamines. | | References | [1] Rothman RB, et, al. (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther. 2003 Jun;305(3):1191-9. DOI:10.1124/jpet.103.049684
[2] Li J, et, al. Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome. Neurochem Res. 2021 Sep;46(9):2249-2261. DOI:10.1007/s11064-021-03358-2 |
| | Norfenfluramine Preparation Products And Raw materials |
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