- p-Xylylene dibromide
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- $2200.00
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2024-05-07
- CAS:623-24-5
- Min. Order: 1Kg
- Purity: 98
- Supply Ability: 500 Kg
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| | alpha,alpha'-Dibromo-p-xylene Basic information |
| | alpha,alpha'-Dibromo-p-xylene Chemical Properties |
| Melting point | 143-145 °C(lit.) | | Boiling point | 245 °C(lit.) | | density | 2.012 | | refractive index | 1.614 | | Fp | 155-158°C/14mm | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | dioxane: soluble1g/10 mL (hot) | | form | Crystalline Powder and Coarse Crystals | | color | White to beige | | Water Solubility | soluble, hydrolyses | | Sensitive | Lachrymatory | | BRN | 1100019 | | InChI | 1S/C8H8Br2/c9-5-7-1-2-8(6-10)4-3-7/h1-4H,5-6H2 | | InChIKey | RBZMSGOBSOCYHR-UHFFFAOYSA-N | | SMILES | BrCc1ccc(CBr)cc1 | | CAS DataBase Reference | 623-24-5(CAS DataBase Reference) | | NIST Chemistry Reference | Benzene, 1,4-bis(bromomethyl)-(623-24-5) | | EPA Substance Registry System | 1,4-Bis(bromomethyl)benzene (623-24-5) |
| Hazard Codes | C | | Risk Statements | 34-22 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3448 6.1/PG 2 | | WGK Germany | 3 | | F | 8-19-21 | | Hazard Note | Corrosive/Lachrymatory | | TSCA | TSCA listed | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29039990 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | alpha,alpha'-Dibromo-p-xylene Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powde | | Uses | It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals. | | Synthesis Reference(s) | Tetrahedron Letters, 35, p. 7055, 1994 DOI: 10.1016/0040-4039(94)88224-X | | Synthesis | 2.3.2.1 Synthesis of 1,4-bis(bromomethyl)benzene 4
In a 250 mL round bottom flask, p-xylene 1 (5 mL, 40.78 mmol) and 70 mL carbon tetrachloride were added as solvents. The flask was heated in an oil bath. Subsequently, N-bromosuccinimide (29.86 g, 167.80 mmol) and benzoyl peroxide (5.83 g, 24.08 mmol) were added sequentially to the flask. The reaction mixture was refluxed at 70 °C for 12 hours. Upon completion of the reaction, the solution was cooled to room temperature, at which point a solid imide precipitated, which was removed by filtration. The filtrate was distilled under reduced pressure to remove the solvent to give the light yellow solid product 1,4-bis(bromomethyl)benzene 4 in 90% yield with a melting point of 142-144 °C. The product was analyzed by FT-IR (KBr, cm^-1) showing 568 (C-Br stretching vibration), 1625 (C=C stretching vibration); 1H NMR (300 MHz, CDCl3) showing 4.28 (s, 4H, methylene proton), 7.18 (s, 4H, aromatic proton). | | Purification Methods | Distil it under a vacuum and recrystallise it from EtOH, *benzene or chloroform. [Wenner Org Chem 17 527 1952, Beilstein 5 H 385, 5 I 187, 5 II 301, 5 III 859, 5 IV 970.] | | References | [1] Tetrahedron Letters, 2000, vol. 41, # 32, p. 6241 - 6244
[2] Tetrahedron Letters, 2005, vol. 46, # 41, p. 7047 - 7050
[3] Synthetic Communications, 2009, vol. 39, # 13, p. 2304 - 2309
[4] Journal of Molecular Catalysis A: Chemical, 2012, vol. 363-364, p. 81 - 89,9
[5] Polyhedron, 2012, vol. 47, # 1, p. 151 - 164 |
| | alpha,alpha'-Dibromo-p-xylene Preparation Products And Raw materials |
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