- Propargyl-PEG5-COOtBu
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2026-07-24
- CAS:1245823-50-0
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
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| | Propargyl-PEG5-t-butyl ester Basic information |
| Product Name: | Propargyl-PEG5-t-butyl ester | | Synonyms: | Alkyne-PEG5-CH2CH2COOtBu;PROPARGYL-PEG5-CH2CH2COOTBU;Propargyl-PEG5-t-butyl ester;Propargyl-PEG5-COOtBu;tert-Butyl 3-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)propanoate;Propargyl-PEG4-CH2CH2-Boc;4,7,10,13,16-Pentaoxanonadec-18-ynoic acid, 1,1-dimethylethyl ester;PropargylPEG5-tBu ester | | CAS: | 1245823-50-0 | | MF: | C18H32O7 | | MW: | 360.44 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1245823-50-0.mol |  |
| | Propargyl-PEG5-t-butyl ester Chemical Properties |
| Boiling point | 420.6±40.0 °C(Predicted) | | density | 1.045±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Liquid | | color | Colorless to light yellow |
| | Propargyl-PEG5-t-butyl ester Usage And Synthesis |
| Description | Propargyl-PEG5-t-butyl ester has one of the functional groups protected by t-butyl group. The protection can be removed under acidic conditions. The propargyl group forms triazole linkages with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The PEG units help improving the water-solubility of the molecule in aqueous media. | | Uses | Propargyl-PEG4-CH2CH2-Boc is a non-cleavable ADC linker that can be used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG4-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-CH2CH2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | Non-cleavable Linker; Alkyl/ether | | References | [1] Zhang H, et al. Thiodigalactoside-Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors. Bioconjug Chem. 2018 Apr 18;29(4):1266-1275. DOI:10.1021/acs.bioconjchem.8b00047 |
| | Propargyl-PEG5-t-butyl ester Preparation Products And Raw materials |
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