| Company Name: |
T&W GROUP |
| Tel: |
021-61551611 13296011611 |
| Email: |
contact@trustwe.com |
- Propargyl-PEG5-NHS
-
-
2026-07-24
- CAS:1393330-40-9
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
|
| | Propargyl-PEG5-NHS ester Basic information |
| Product Name: | Propargyl-PEG5-NHS ester | | Synonyms: | Propargyl-PEG4-CH2CH2COONHS;Propargyl-PEG5-NHS ester;Alkyne-PEG4-NHS Ester;4,7,10,13,16-Pentaoxanonadec-18-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester;4,7,10,13,16-Pentaoxanonadec-18-ynoic Acid N-Succinimidyl Ester;Propargyl-PEG4-Osu;2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16-pentaoxanonadec-18-yn-1-oate;Propargyl-PEG4-CH2CH2COONHS/4,7,10,13,16-Pentaoxanonadec-18-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester | | CAS: | 1393330-40-9 | | MF: | C18H27NO9 | | MW: | 401.41 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1393330-40-9.mol |  |
| | Propargyl-PEG5-NHS ester Chemical Properties |
| Boiling point | 497.6±55.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | -20°C, protect from light | | solubility | DMSO : 100 mg/mL (249.12 mM; Need ultrasonic) | | form | clear liquid | | color | Light yellow to Brown | | Appearance | Light yellow oil |
| | Propargyl-PEG5-NHS ester Usage And Synthesis |
| Description | Propargyl-PEG5-NHS ester has a propargyl group and an NHS ester group. The terminal NHS ester and is an amine reactive moeity which is useful for derivatizing peptides, antibodies, amine coated surfaces etc. The propargyl group can participate in Click Chemistry reactions with azide compounds, copper is needed for catalyzation. The PEG units can enhance the hydrophilicity of the molecule. | | Uses | Propargyl-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG5-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | Cleavable Linker; PEGs; Alkyl/ether | | References | [1] Zhenjun Diwu, et al. Polyfluoreno[4,5-cde]oxepine Conjugates and Their Use in Methods of Analyte Detection. US20170275418A1. |
| | Propargyl-PEG5-NHS ester Preparation Products And Raw materials |
|