t-Boc-N-Amido-PEG2-Propargyl manufacturers
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| | t-Boc-N-Amido-PEG2-Propargyl Basic information |
| Product Name: | t-Boc-N-Amido-PEG2-Propargyl | | Synonyms: | t-Boc-N-Amido-PEG2-Propargyl;Propargyl-PEG2-NHBoc;N-Boc-2-[2-(2-propyn-1-yloxy)ethoxy]ethanamine;Propargyl-PEG3-Boc Amine;tert-butyl N-[2-(2-prop-2-ynoxyethoxy)ethyl]carbamate;Carbamic acid, N-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester;tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate | | CAS: | 869310-84-9 | | MF: | C12H21NO4 | | MW: | 243.3 | | EINECS: | | | Product Categories: | | | Mol File: | 869310-84-9.mol |  |
| | t-Boc-N-Amido-PEG2-Propargyl Chemical Properties |
| Boiling point | 344.2±27.0 °C(Predicted) | | density | 1.033±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Liquid | | pka | 12.22±0.46(Predicted) | | color | Colorless to light yellow |
| | t-Boc-N-Amido-PEG2-Propargyl Usage And Synthesis |
| Description | t-Boc-N-Amido-PEG2-propargyl is crosslinker consisting of a propargyl group and a t-Boc protected amine group. The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The t-Boc protected amine can be deprotected under mild acidic conditions. | | Uses | Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-NHBoc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | Cleavable Linker; PEGs; Alkyl/ether | | References | [1] Nello Mainolfi, et al. rak degraders and uses thereof. US20190192668A1. |
| | t-Boc-N-Amido-PEG2-Propargyl Preparation Products And Raw materials |
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