(Hydroxymethyl)-2-pyrrolidinone

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(Hydroxymethyl)-2-pyrrolidinone Basic information
Uses
Product Name:(Hydroxymethyl)-2-pyrrolidinone
Synonyms:N-HYDROXYMETHYL PYRROLIDONE;1-(HYDROXYMETHYL)PYRROLIDIN-2-ONE;METHYLOLPYRROLIDONE;IFLAB-BB F0861-0038;1-(Hydroxymethyl)-2-pyrrolizinone;1-Hydroxymethyl-2-pyrrolidone;1-Hydroxymethyl-2-pyrrolidinone;2-Pyrrolidinone, 1-(hydroxymethyl)-
CAS:15438-71-8
MF:C5H9NO2
MW:115.13
EINECS:239-451-5
Product Categories:
Mol File:15438-71-8.mol
(Hydroxymethyl)-2-pyrrolidinone Structure
(Hydroxymethyl)-2-pyrrolidinone Chemical Properties
Melting point 77-79.5 °C
Boiling point 185-188 °C(Press: 4 Torr)
density 1.213±0.06 g/cm3(Predicted)
pka13.41±0.10(Predicted)
CAS DataBase Reference15438-71-8(CAS DataBase Reference)
EPA Substance Registry System2-Pyrrolidinone, 1-(hydroxymethyl)- (15438-71-8)
Safety Information
TSCA TSCA listed
MSDS Information
(Hydroxymethyl)-2-pyrrolidinone Usage And Synthesis
Uses1-(hydroxymethyl)pyrrolidone-2-one can be used as a pharmaceutical synthesis intermediate. If 1-(hydroxymethyl)pyrrolidone-2-one is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and thoroughly wash the skin with soap and water. If discomfort persists, seek medical attention.
Synthesis

1-(Hydroxymethyl)pyrrolidin-2-one was prepared as follows: 2-pyrrolidinone (212.4 g, 2.0 mol) and potassium hydroxide (0.6 g) were heated to 80 C and oligoformaldehyde (75.6 g, 2.6 mol) was added within 10 min and the mixture was kept at 75 C - 80 C for 1/2 hour. The desired product was then crystallized from 1 part benzene to give 227 g of 1-(hydroxymethyl)pyrrolidin-2-one (88.2%) with a melting point product at 78°-80°C.

(Hydroxymethyl)-2-pyrrolidinone Preparation Products And Raw materials
Tag:(Hydroxymethyl)-2-pyrrolidinone(15438-71-8) Related Product Information
(S)-N-alpha-t-Butyloxycarbonyl-pyroglutamic acid t-butyl ester Boc-Pyr-OH Z-D-Pyr-OH Z-Pyr-OH (R)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,(R)-(-)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,5-(Hydroxymethyl)-2-pyrrolidinone (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate (S)-(+)-5-HYDROXYMETHYL-2-PYRROLIDINONE 97%,(S)-(+)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,(S)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE Streptolydigin Z-Pyr-OSu Z-pGlu-Pro-OBzl (Hydroxymethyl)-2-pyrrolidinone Boc-Pyr-OH dcha (+)-(3R,7aS)-Tetrahydro-3-phenyl-3H,5H-pyrrolo1,2-coxaole-5-one N-hydroxymethylsuccinimide 1-(tert-Butoxycarbonyl)-2-pyrrolidinone Z-Pyr-ONp (S)-1-Benzyl-5-hydroxymethyl-2-pyrrolidinone (4R)-Boc-4-benzyl-Pyr-OH