(Hydroxymethyl)-2-pyrrolidinone

Request For Quotation
(Hydroxymethyl)-2-pyrrolidinone Suppliers list
Company Name: TaiChem Taizhou Limited  
Tel: 052386810091
Email: zcwy9518@yeah.net
Company Name: Yantai ShengKailun Chemical Technology Co., Ltd.  
Tel: 13356901049
Email: 3119594100@qq.com
Company Name: Jiangsu aikang biomedical research and development co., LTD  
Tel: 025-58859352 17714375163
Email: qzhang@aikonchem.com
Company Name: Career Henan Chemica Co  
Tel: +86-0371-86658258 +86-13203830695
Email: laboratory@coreychem.com
Company Name: Beijing xinyanhui pharmaceutical research and development co., LTD  
Tel: 13969155946
Email: 1461866103@qq.com
(Hydroxymethyl)-2-pyrrolidinone Basic information
Uses
Product Name:(Hydroxymethyl)-2-pyrrolidinone
Synonyms:N-HYDROXYMETHYL PYRROLIDONE;1-(HYDROXYMETHYL)PYRROLIDIN-2-ONE;METHYLOLPYRROLIDONE;IFLAB-BB F0861-0038;1-(Hydroxymethyl)-2-pyrrolizinone;1-Hydroxymethyl-2-pyrrolidone;1-Hydroxymethyl-2-pyrrolidinone;2-Pyrrolidinone, 1-(hydroxymethyl)-
CAS:15438-71-8
MF:C5H9NO2
MW:115.13
EINECS:239-451-5
Product Categories:
Mol File:15438-71-8.mol
(Hydroxymethyl)-2-pyrrolidinone Structure
(Hydroxymethyl)-2-pyrrolidinone Chemical Properties
Melting point 77-79.5 °C
Boiling point 185-188 °C(Press: 4 Torr)
density 1.213±0.06 g/cm3(Predicted)
pka13.41±0.10(Predicted)
CAS DataBase Reference15438-71-8(CAS DataBase Reference)
EPA Substance Registry System2-Pyrrolidinone, 1-(hydroxymethyl)- (15438-71-8)
Safety Information
TSCA TSCA listed
MSDS Information
(Hydroxymethyl)-2-pyrrolidinone Usage And Synthesis
Uses1-(hydroxymethyl)pyrrolidone-2-one can be used as a pharmaceutical synthesis intermediate. If 1-(hydroxymethyl)pyrrolidone-2-one is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and thoroughly wash the skin with soap and water. If discomfort persists, seek medical attention.
Synthesis

1-(Hydroxymethyl)pyrrolidin-2-one was prepared as follows: 2-pyrrolidinone (212.4 g, 2.0 mol) and potassium hydroxide (0.6 g) were heated to 80 C and oligoformaldehyde (75.6 g, 2.6 mol) was added within 10 min and the mixture was kept at 75 C - 80 C for 1/2 hour. The desired product was then crystallized from 1 part benzene to give 227 g of 1-(hydroxymethyl)pyrrolidin-2-one (88.2%) with a melting point product at 78°-80°C.

(Hydroxymethyl)-2-pyrrolidinone Preparation Products And Raw materials
Tag:(Hydroxymethyl)-2-pyrrolidinone(15438-71-8) Related Product Information
(S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate (S)-(+)-5-HYDROXYMETHYL-2-PYRROLIDINONE 97%,(S)-(+)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,(S)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE Streptolydigin Z-D-PYR-OH (S)-N-ALPHA-T-BUTYLOXYCARBONYL-PYROGLUTAMIC ACID T-BUTYL ESTER BOC-PYR-OH (R)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,(R)-(-)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,5-(Hydroxymethyl)-2-pyrrolidinone Z-Pyr-OH N-hydroxymethylsuccinimide 1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE (+)-(3R,7aS)-Tetrahydro-3-phenyl-3H,5H-pyrrolo1,2-coxaole-5-one (4R)-BOC-4-BENZYL-PYR-OH Z-PYR-ONP Z-PGLU-HIS-OH (S)-1-BENZYL-5-HYDROXYMETHYL-2-PYRROLIDINONE (R)-5-HYDROXYMETHYL-2-PYRROLIDINONE P-TOLUENESULFONATE Boc-Pyr-OH dcha (Hydroxymethyl)-2-pyrrolidinone