- EEDQ
-
- $1980.00
-
2026-08-29
- CAS:16357-59-8
- Purity:
- Supply Ability: 10g
|
| | N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Basic information |
| Product Name: | N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline | | Synonyms: | N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline≥ 99% (HPLC);Ethyl 2-ethoxy-1,2-dihydro-1-quinolinecarboxylate for synthesis;EEDQ~N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline;ethyl N-(2-ethoxy-1,2-dihydroquinoline)carboxylate;N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline ,98%;N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, 99+% 100GR;ETHYL 2-ETHOXY-1,2-DIHYDRO-1-QUINOLINECA;2-Ethoxy-1-ethoxycarbonyl-1.2-dihydroquinoline 1g [16357-59-8] | | CAS: | 16357-59-8 | | MF: | C14H17NO3 | | MW: | 247.29 | | EINECS: | 240-418-2 | | Product Categories: | Acids and Derivatives;Heterocycles;Coupling Reagent;Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);Peptide Synthesis;Synthetic Organic Chemistry | | Mol File: | 16357-59-8.mol |  |
| | N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Chemical Properties |
| Melting point | 62-67 °C(lit.) | | Boiling point | 125-128 °C (0.1 mmHg) | | density | 1.1173 (rough estimate) | | refractive index | 1.5300 (estimate) | | Fp | 125-128°C/0.1mm | | storage temp. | 2-8°C | | solubility | Chlorofrom (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | pka | -1.27±0.40(Predicted) | | form | Crystalline Powder | | color | White to beige | | Water Solubility | insoluble | | Sensitive | Moisture Sensitive | | Merck | 14,3518 | | BRN | 533048 | | Major Application | peptide synthesis | | InChI | 1S/C14H17NO3/c1-3-17-13-10-9-11-7-5-6-8-12(11)15(13)14(16)18-4-2/h5-10,13H,3-4H2,1-2H3 | | InChIKey | GKQLYSROISKDLL-UHFFFAOYSA-N | | SMILES | CCOC1C=Cc2ccccc2N1C(=O)OCC | | CAS DataBase Reference | 16357-59-8(CAS DataBase Reference) | | EPA Substance Registry System | 1(2H)-Quinolinecarboxylic acid, 2-ethoxy-, ethyl ester (16357-59-8) |
| Hazard Codes | Xi,Xn | | Risk Statements | 38-36/37/38-20/21/22 | | Safety Statements | 22-24/25-36/37/39-26-36 | | WGK Germany | 3 | | RTECS | VB2010000 | | F | 9-21 | | TSCA | TSCA listed | | HS Code | 29334990 | | Storage Class | 11 - Combustible Solids | | Toxicity | mouse,LD50,intraperitoneal,32mg/kg (32mg/kg),Journal of Medicinal Chemistry. Vol. 14, Pg. 49, 1971. |
| | N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Usage And Synthesis |
| Chemical Properties | White to pale yellow solid | | Uses | Peptide condensing agent with little or no racemization. Amidation coupling reagent. | | Uses | In the synthesis of peptides. | | Uses | 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline is an irreversible membrane-bound receptor antagonist. It is used in synthetic chemistry, discovery, process R&D. It also acts as coupling reagents. | | Application | N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline is used as a coupling agent:
In the regioselective quaternization of chitosan and its amphiphilic derivatives.
In the preparation of amide-type S-MA derivative-modified QCM sensors. | | reaction suitability | reaction type: Coupling Reactions | | Purification Methods | Dissolve EEDQ ~180g in CHCl3, evaporate to dryness in a vacuum. Add dry Et2O (20mL) and a white solid separates on standing. Set aside for a few hours, collect the solid, wash it thoroughly with cold Et2O and dry it in a vacuum (~140g, m 63.5-65o). A further crop of solid (~25g) is obtained from the filtrate on standing overnight. [Fieser & Fieser Reagents for Organic Synthesis 2 191 1969, Belleau et al. J Am Chem Soc 90 823 1968 and 90 1651 1968, Beilstein 21/3 V 28.] |
| | N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Preparation Products And Raw materials |
|