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Ark Pharm, Inc. |
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847-367-3680 |
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sales@arkpharminc.com |
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Energy Chemical |
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| | 3-Amino-6-bromopyrazine-2-carboxylic acid Basic information |
| Product Name: | 3-Amino-6-bromopyrazine-2-carboxylic acid | | Synonyms: | 3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLIC ACID;3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLIC ACID, 95+%;3-AMINO-6-BROMOPYRAZINE-2-CARB;3-AMino-6-broMo-2-pyrazinecarboxylic Acid;2-Amino-5-bromo-3-carboxypyrazine, 2-Amino-5-bromo-3-carboxy-1,4-diazine;2-Pyrazinecarboxylic acid, 3-amino-6-bromo-;3-Amino-6-bromopyrazine-2-carboxylicacid,98%;3-Amino-6-bromopyrazine-2-carboxylicaci | | CAS: | 486424-37-7 | | MF: | C5H4BrN3O2 | | MW: | 218.01 | | EINECS: | 802-115-9 | | Product Categories: | Bases & Related Reagents;Nucleotides | | Mol File: | 486424-37-7.mol |  |
| | 3-Amino-6-bromopyrazine-2-carboxylic acid Chemical Properties |
| Melting point | 178-183℃ | | Boiling point | 397.8±42.0 °C(Predicted) | | density | 2.039±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | Soluble in dimethyl sulfoxide and methanol. | | pka | 3.26±0.10(Predicted) | | form | Solid | | color | Pale yellow | | Sensitive | Light Sensitive | | InChI | InChI=1S/C5H4BrN3O2/c6-2-1-8-4(7)3(9-2)5(10)11/h1H,(H2,7,8)(H,10,11) | | InChIKey | MTNAQEKMSVDTAQ-UHFFFAOYSA-N | | SMILES | C1(C(O)=O)=NC(Br)=CN=C1N |
| WGK Germany | WGK 3 | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Dam. 1 |
| | 3-Amino-6-bromopyrazine-2-carboxylic acid Usage And Synthesis |
| Chemical Properties | Yellow Solid | | Uses | 3-Amino-6-bromopyrazine-2-carboxylic acid used to prepare 3-bromo-5-phenylpyrazine-2-amine. It serves as an intermediate in organic synthesis and pharmaceuticals. | | Synthesis | Step 2: Methyl 3-amino-6-bromopyrazine-2-carboxylate (5.11 g, 22.02 mmol) and lithium hydroxide (2.637 g, 110.1 mmol) were dissolved in a mixed solvent of methanol (20 mL) and water (20 mL), heated to 90 °C, and the reaction was carried out for 2 hours. After completion of the reaction, the reaction mixture was cooled, neutralized with hydrochloric acid to pH neutral, and the precipitated solid was collected by filtration. The resulting 3-amino-6-bromopyrazine-2-carboxylic acid was used directly in the next step of the reaction without further purification (4.80 g, 99% yield). | | References | [1] Patent: WO2011/143419, 2011, A1. Location in patent: Page/Page column 44-45
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 8, p. 2784 - 2788
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2320 - 2330
[4] Patent: WO2017/123588, 2017, A1. Location in patent: Paragraph 0031; 0032; 0033
[5] Patent: WO2010/54398, 2010, A1. Location in patent: Page/Page column 90 |
| | 3-Amino-6-bromopyrazine-2-carboxylic acid Preparation Products And Raw materials |
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