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| | Capillarisin Basic information |
| Product Name: | Capillarisin | | Synonyms: | CAPILLARISIN;Capillarisin std.;CAPILLARISIN(RG);CAPILLARISIN hplc;5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxychromen-4-one;5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one;2-(4-Hydroxyphenoxy)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one;5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-1-benzopyran-4-one | | CAS: | 56365-38-9 | | MF: | C16H12O7 | | MW: | 316.26 | | EINECS: | | | Product Categories: | Flavones | | Mol File: | 56365-38-9.mol |  |
| | Capillarisin Chemical Properties |
| Melting point | approximate 225℃ (dec.) | | Boiling point | 582.6±50.0 °C(Predicted) | | density | 1.551±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder | | pka | 6.37±0.40(Predicted) | | color | Light yellow to yellow |
| | Capillarisin Usage And Synthesis |
| Uses | Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity[1][2][3]. | | Definition | ChEBI: Capillarisin is a member of coumarins. | | in vivo | Capillarisin (20 and 80 mg/kg; i.p.; 1 hour) pretreatment strongly inhibits NF-κB mediated genes (iNOS, COX-2)[4].
Capillarisin significantly reduces the plasma leading nitrite production. Capillarisin markedly suppresses the adenosine 5'-triphosphate (ATP) in plasma and substance P in CFA-induced paw tissue[4]. | Animal Model: | ICR mice[4] | | Dosage: | 20 and 80 mg/kg | | Administration: | I.p.; 1 hour | | Result: | Pretreatment strongly inhibited NF-κB mediated genes (iNOS, COX-2).
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| | target | TLR | NF-kB | MAPK | STAT | TNF-α | IL Receptor | NO | PGE | AP-1 | ERK | NOS | COX | MMP(e.g.TIMP) | VEGFR | JNK | Bcl-2/Bax | | References | [1] Peng G, et al. Capillarisin exerts antiasthmatic activity in neonatal rats via modulating the matrix remodeling. Pak J Pharm Sci. 2020;33(4(Supplementary)):1907-1915. PMID:33612476
[2] Komiya T, et al. Capillarisin, a Constituent from Artemisiae Capillaris Herba. Chemical and Pharmaceutical Bulletin, 1975
[3] Zhao T, Wang Q. Capillarisin protects SH-SY5Y cells against bupivacaine-induced apoptosis via ROS-mediated PI3K/PKB pathway. Life Sci. 2020;259:118279. DOI:10.1016/j.lfs.2020.118279
[4] Khan S, et al. Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model. J Ethnopharmacol. 2014;152(3):478-486. DOI:10.1016/j.jep.2014.01.028 |
| | Capillarisin Preparation Products And Raw materials |
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