| Company Name: |
Nextpeptide Inc |
| Tel: |
+86-0571-81612335 +8613336028439 |
| Email: |
sales@nextpeptide.com |
|
| | H-LEU-4M-BETANA HCL Basic information |
| Product Name: | H-LEU-4M-BETANA HCL | | Synonyms: | L-LEUCYL-4-METHOXY-B-NAPHTHYLAMIDE HYDROCHLORIDE;L-LEU-4-METHOXY-BETA-NAPHTHYLAMIDE HCL;L-LEUCINE 4-METHOXY-BETA-NAPHTHYLAMIDE HYDROCHLORIDE;LEUCINE-4M-BETANA HCL;L-leucine 4-methoxy-B-naphthylamide*hydrochloride;(S)-2-amino-N-(4-methoxy-2-naphthyl)-4-methylvaleramide monohydrochloride;H-Leu-4MbNA·HCl;L-Leucine 4-methoxy-β-naphthylamide hydrochloride | | CAS: | 4467-68-9 | | MF: | C17H23ClN2O2 | | MW: | 322.83 | | EINECS: | 2247353 | | Product Categories: | | | Mol File: | 4467-68-9.mol |  |
| | H-LEU-4M-BETANA HCL Chemical Properties |
| storage temp. | 2-8°C | | solubility | ≤25mg/ml in ethanol;10mg/ml in DMSO;20mg/ml in dimethyl formamide | | form | crystalline solid |
| Hazard Codes | Xn | | Risk Statements | 40 | | Safety Statements | 22-36 | | WGK Germany | 3 |
| | H-LEU-4M-BETANA HCL Usage And Synthesis |
| Description | L-Leucine 4-methoxy-β-naphthylamide is a cell-permeable substrate for aminopeptidase M and leucine aminopeptidase that was developed for intracellular analysis of protease activities. | | Chemical Properties | Crystalline | | Uses | L-Leucine 4-methoxy-β-naphthylamide is a cell-permeable substrate for aminopeptidase M and leucine aminopeptidase that was developed for intracellular analysis of protease activities. | | in vitro | l-leucine 4-methoxy-β-naphthylamide was identified as a cell-permeable substrate for aminopeptidase m and leucine aminopeptidase that was developed for intracellular analysis of protease activities [1]. in a previous method-developing study, peptide derivatives of 4-methoxy-β-naphthylamine including l-leucine 4-methoxy-β-naphthylamide were incubated in microtiter plates together with nitrosalicylaldehyde. selectivity was achieved by running parallel assays containing inhibitors partially selective for each of peptide derivatives. this method was successfully validated by measurements in cells isolated from cathepsin b-/--, k-/--, and l-/-- mice [2]. | | references | [1] monis, b. ,wasserkrug, h. and seligman, a.m. comparison of fixatives and substrates for aminopeptidase. journal of histochemistry and cytochemistry 13(6), 503-509 (1965).
[2] rüttger, a. ,mollenhauer, j.,lser, r., et al. microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-β-naphthylamide. biotechniques 41(4), 469-473 (2006). |
| | H-LEU-4M-BETANA HCL Preparation Products And Raw materials |
|