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Thalidomide-NH-C4-NH-Boc manufacturers
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| | Thalidomide-NH-C4-NH-Boc Basic information |
| Product Name: | Thalidomide-NH-C4-NH-Boc | | Synonyms: | Thalidomide-NH-C4-NH-Boc;Carbamic acid, N-[4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]butyl]-, 1,1-dimethylethyl ester;Pomalidomide-NH-C4-NH-Boc;tert-butyl (4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)carbamate;E3 Ligase Ligand-Linker Conjugates,PROTAC,Thalidomide,ThalidomideNHC4NHBoc,Thalidomide-NH-C-4-NH-Boc,Inhibitor,inhibit,Thalidomide NH C4 NH Boc;Thalidomide-4-NH-C4-NH-Boc;Thalidomide-NH-C4-NH-Boc ，S6397;tert-butyl (4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)carbamate | | CAS: | 2093388-52-2 | | MF: | C22H28N4O6 | | MW: | 444.48 | | EINECS: | | | Product Categories: | | | Mol File: | 2093388-52-2.mol |  |
| | Thalidomide-NH-C4-NH-Boc Chemical Properties |
| Boiling point | 704.0±60.0 °C(Predicted) | | density | 1.324±0.06 g/cm3(Predicted) | | solubility | DMSO : 100 mg/mL (224.98 mM; Need ultrasonic) | | pka | 10.75±0.40(Predicted) | | form | Solid | | color | Yellow to green |
| | Thalidomide-NH-C4-NH-Boc Usage And Synthesis |
| Uses | Thalidomide-NH-C4-NH-Boc (compound 15) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | | IC 50 | Cereblon | | References | [1] Jiang F, et al.Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181. DOI:10.1016/j.bmc.2019.115181 |
| | Thalidomide-NH-C4-NH-Boc Preparation Products And Raw materials |
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