(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine

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Company Name:	Hebei Yanxi Chemical Co., Ltd.
Tel:	+8618531123677
Email:	faithe@yan-xi.com
Products Intro:	Product Name:(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine CAS:147081-44-5 Purity:0.99 Package:1kg;20USD\|100kg;10USD\|1000kg;1USD Remarks:Factory direct sales

Company Name:	Hebei Chuanghai Biotechnology Co., Ltd
Tel:	+8615531151365
Email:	mina@chuanghaibio.com
Products Intro:	Product Name:(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine CAS:147081-44-5 Purity:99% Package:200KG;0.00;USD

Company Name:	Hefei Lbao Physical & Chemical Science Co.,Ltd
Tel:	+1-5184799099
Email:	lbaochemicals@gmail.com
Products Intro:	Product Name:(S)-1-Boc-3-Aminopyrrolidine CAS:147081-44-5 Purity:98% Package:1kg

Company Name:	Capot Chemical Co.,Ltd.
Tel:	+86-（0）57185586718; +8613336195806
Email:	sales@capot.com
Products Intro:	Product Name:(S)-(-)-1-Boc-3-aminopyrrolidine CAS:147081-44-5 Purity:98% (Min,HPLC) Package:1G;1KG;100KG

Company Name:	Shanghai Daken Advanced Materials Co.,Ltd
Tel:	+86-2158073036
Email:	info@dakenam.com
Products Intro:	Product Name:(S)-1-tert-Butyloxycarbonyl-3-aminopyrrolidine CAS:147081-44-5 Purity:99% Package:1KG,5KG,10KG

(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine manufacturers

(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine Basic information

Product Name:	(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine
Synonyms:	(s)-n-boc-3-aminopyrrolidine;tert-Butyl (3S)-3-aminopyrrolidine-1-carboxylate;tert-Butyl (3S)-3-aminopyrrolidine-1-carboxylate, (3S)-3-Amino-1-(tert-butoxycarbonyl)pyrolidine;1-t-butoxycarbonyl-3-S-aMinopyrrolidine;(3S)-(-)-1-Boc-3-aminopyrrolidine (3S)-(-)-3-Amino-1-(tert-butoxycarbonyl)pyrrolidine (3S)-(-)-3-Amino-1-Boc-pyrrolidine;(S)-3-Amino-n-boc-pyrr;(S)-3-Amino-1-Boc-pyrroli...;(3S)-3-Aminopyrrolidine, N1-BOC protected
CAS:	147081-44-5
MF:	C9H18N2O2
MW:	186.25
EINECS:	627-302-0
Product Categories:	Chiral Building Blocks;Heterocyclic Building Blocks;Pyrrolidines;Benzenes;3-Aminopyrrolidines;Chiral 3-Aminopyrrolidines;pharmacetical;chiral;Pyrrole&Pyrrolidine&Pyrroline
Mol File:	147081-44-5.mol

(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine Chemical Properties

alpha	-2 º (c=1, chloroform)
Boiling point	216-217 °C(lit.)
density	1.067 g/mL at 25 °C(lit.)
refractive index	n20/D 1.4720(lit.)
Fp	196 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
pka	9.55±0.20(Predicted)
form	Liquid
color	Clear colorless to yellow
Optical Rotation	[α]20/D 2°, c = 1 in chloroform
Sensitive	Air Sensitive
BRN	8312125
InChI	InChI=1S/C9H18N2O2/c1-9(2,3)13-8(12)11-5-4-7(10)6-11/h7H,4-6,10H2,1-3H3/t7-/m0/s1
InChIKey	CMIBWIAICVBURI-ZETCQYMHSA-N
SMILES	N1(C(OC(C)(C)C)=O)CC[C@H](N)C1
CAS DataBase Reference	147081-44-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,C,Xi
Risk Statements	22-41
Safety Statements	26
RIDADR	UN 2810 6.1/PG 3
WGK Germany	2
HazardClass	8
PackingGroup	III
HS Code	29339900
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral Eye Dam. 1

MSDS Information

Provider	Language
(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine	English
SigmaAldrich	English
ALFA	English

(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine Usage And Synthesis

Chemical Properties	Colorless to light yellow liqui
Uses	(S)-(-)-1-Boc-3-aminopyrrolidine may be used to prepare: Descarboxamide analog of 4-N-(N^ω-nitro-L-argininyl)-trans-4-amino-L-proline amide. Histamine 3 (H₃) receptor antagonists containing pyrrolidin-3-yl-N-methylbenzamide moiety.
Synthesis	125552-56-9 147081-44-5 To a solution of compound 178 (2.0 g, 9.42 mmol, 1.0 eq.) in methanol (40 mL) was added palladium carbon (1.0 g, 0.94 mmol, 0.1 eq.). The reaction mixture was subjected to hydrogenation at atmospheric pressure and room temperature for 6 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. The target compound (S)-1-Boc-3-aminopyrrolidine was obtained as a yellow oil (1.7 g, 97% yield).
References	[1] Patent: US2009/221565, 2009, A1. Location in patent: Page/Page column 51 [2] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00470 [3] Patent: CN105399698, 2016, A. Location in patent: Paragraph 1340-1342 [4] Patent: WO2005/811, 2005, A1. Location in patent: Page/Page column 61 [5] Patent: WO2005/20975, 2005, A2. Location in patent: Page/Page column 221

(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Ammonium hydroxide-->Isopropyl alcohol-->Di-tert-butyl dicarbonate-->1-Butanol-->(3S)-(+)-3-Aminopyrrolidine dihydrochloride-->tert-Butyl (3S)-3-(trifluoroacetamido)pyrrolidine-1-carboxylate-->(R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester-->(3S)-1-Boc-3-azido-pyrrolidine-->ethyl 2-chloro-4-ethoxy-nicotinate
Preparation Products	Leniolisib-->(S)-3-(2-Chloro-pyrimidin-4-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester-->1-Pyrrolidinecarboxylic acid, 3-[(2-ethoxy-2-oxoethyl)amino]-, 1,1-dimethylethyl ester, (3S)--->Isopropyl-Methyl-(S)-pyrrolidin-3-yl-aMine

Tag:(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine(147081-44-5) Related Product Information

(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate (2S,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate hydrochloride N-Boc-cis-4-Fmoc-Amino-L-proline (3R,4R)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE (2S,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate (3r)-(+)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine,(R)-(+)-N-tert-Butoxycarbonyl-3-aminopyrrolidine 1-TERT-BUTOXYCARBONYL-3-AMINOPYRROLIDINE (S)-3-Aminopyrrolidine 3-Aminopyrrolidine trans-3-Amino-4-(4-methylphenyl)pyrrolidine, N-BOC protected (S)-(+)-N-BOC-3-N-FMOC-AMINOPYRROLIDINE& 3-AMINO-4-PHENYLPYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (S)-1-BOC-3-N-(PYRIDIN-4-YLMETHYL)-AMINO-PYRROLIDINE (S)-(+)-N-BOC-4-AMINO-L-PROLINE, 97 (2S,4S)-BOC-4-(BOC-AMINO)-PROLINE (2S,4S)-1-BOC-2-HYDROXYMETHYL-4-AMINO PYRROLIDINE-HCL

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