- Levamisole hydrochloride
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- $0.00 / 1Kg/Bag
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2025-10-17
- CAS:16595-80-5
- Min. Order: 1KG
- Purity: 98.5%-101%; EP
- Supply Ability: 1000 KGS
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| | Levamisole hydrochloride Basic information |
| Product Name: | Levamisole hydrochloride | | Synonyms: | 1-b)thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,(s)-imidazo(;1-b)thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,l-(-)-imidazo(;1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,(S)-Imidazo[2;citarinl;decaris;Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,(S)-;kw-2-le-t;L-2,3,5,6-Tetrahydro-6-phenylimidazo-[2,1-6]-thiazole | | CAS: | 16595-80-5 | | MF: | C11H13ClN2S | | MW: | 240.75 | | EINECS: | 240-654-6 | | Product Categories: | Other APIs;REZIFILM;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Pharma;Pharmaceutical intermediate;Antibiotic Explorer;Veterinaries;Protein Phosphatase;Asymmetric Synthesis;Synthetic Organic Chemistry;API;16595-80-5 | | Mol File: | 16595-80-5.mol |  |
| | Levamisole hydrochloride Chemical Properties |
| Melting point | 266-267 °C(lit.) | | alpha | -128 º (c=5, H2O) | | refractive index | -126 ° (C=1, H2O) | | Fp | 9℃ | | storage temp. | 2-8°C | | solubility | Freely soluble in water, soluble in ethanol (96 per cent), slightly soluble in methylene chloride. | | form | Crystalline Powder | | color | White to almost white | | biological source | synthetic (organic) | | Optical Rotation | Consistent with structure | | Water Solubility | 210 g/L (20 ºC) | | Merck | 14,5459 | | BRN | 4358988 | | BCS Class | 3/1 | | Stability: | Hygroscopic | | InChI | InChI=1/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/s3 | | InChIKey | LAZPBGZRMVRFKY-HNCPQSOCSA-N | | SMILES | [C@H]1(N=C2SCCN2C1)C1=CC=CC=C1.Cl |&1:0,r| | | LogP | 1.845 (est) | | CAS DataBase Reference | 16595-80-5(CAS DataBase Reference) | | EPA Substance Registry System | Levamisole hydrochloride (16595-80-5) |
| | Levamisole hydrochloride Usage And Synthesis |
| Chemical Properties | White to light yellow crystalline powder, odorless, bitter taste. Melting point 227-229℃. Soluble in water, methanol, ethanol and glycerol, slightly soluble in chloroform and aether; insoluble in acetone. Stable under acidic conditions, but easy to decompose and fail under alkaline conditions. | | Originator | Solaskil,Specia,France,1971 | | Uses | Biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator. | | Uses | Levamisole hydrochloride is an anthelmintic. The activity of levamisole is about twice as high as that of abscisicidal, and the toxicity and side effects are lower. Levamisole can cause muscle paralysis of roundworms and then excrete them in the feces. It is mainly used as an anti-worm and anti-hookworm. | | Preparation | Levamisole hydrochloride was prepared from racemic tetraimidazole by splitting, alkali analysis and acidification into salt.
Dibenzoyl-D-tartaric acid is boiled in water for 40min, hydrolyzed and neutralized with sodium hydroxide solution to pH 7.5, and then added to racemic tetraimidazole. The levamisole is precipitated by generating salt with bisbenzoyl-tartaric acid. After separation, add sodium hydroxide solution to PH=9 and decompose levamisole. Then dissolved in dilute hydrochloric acid solution, after decolorization by activated carbon, the filtrate was concentrated nearly dry, and crystallized by adding acetone and cooling to 0℃. Filtered and dried to obtain levamisole hydrochloride. | | Definition | ChEBI: Levamisole hydrochloride is an organic molecular entity. | | Brand name | Ergamisol (Janssen);Vermisol. | | Therapeutic Function | Antiinflammatory | | Biochem/physiol Actions | Shows both immunostimulant and immunosuppressant effects, depending on several controllable factors. Very effective in treatment of ascariasis (hookworm infestation). Useful in chemotherapy of colorectal cancers, possibly due to its stimulation of IL-1 production and direct activation of macrophages. | | Pharmacokinetics | Levamisole is rapidly absorbed from all routes of administration, with peak blood levels occurring within an hour followed by rapid metabolism and depletion principally via urinary excretion, with an elimination half-life of approximately 4 h. | | Pharmacology | Levamisole Hydrochloride is the hydrochloride salt of the synthetic imidazothiazole derivative levamisole with anthelminthic and immunomodulating activities. In immunosuppressed states, levamisole may restore immune function by: 1) stimulating antibody formation, 2) stimulating T-cell activation and proliferation, 3) potentiating monocyte and macrophage phagocytosis and chemotaxis and 4) increasing neutrophil mobility, adherence, and chemotaxis. | | Side effects | Levamisole hydrochloride oral side effects are dose-related, mild and transient. The most common side effects are fever and gastrointestinal symptoms. Other possible side effects include: rash, changes in taste and smell, granulocytopenia and/or leukopenia, arthralgia/myalgia, convulsions, failure, peripheral neuropathy, tachycardia, thrombocytopenia, vasculitis, and vertigo. | | Synthesis | To a 1000 mL four-necked flask was added 50 g of (S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (L-tetramidazole) followed by 500 g of isopropanol. The mixture was heated until completely dissolved, then 0.5 g of activated carbon and 0.75 g of sodium bisulfite were added and the decolorization process was carried out with continuous stirring for 30 minutes. After completion of the reaction, the solid impurities were removed by filtration. Hydrogen chloride gas 9 g was passed into the filtrate to adjust the pH to 4-5. filtering again, the solid product was collected, i.e., (S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride (levamisole hydrochloride), which was obtained after drying to give 54.3 g with a yield of 92.1 %. The resulting product was a colorless bulk solid with stable quality under long-term storage conditions. | | Mode of action | Levamisole is a cholinergic receptor agonist and elicits spastic muscle paralysis due to prolonged activation of the excitatory nicotinic acetylcholine receptors (nAChR) on nematode body wall muscle. | | Toxicity evaluation | Symptoms of levamisole toxicity mimic organophosphate toxicity (salivation, lacrimation, urination and defecation, hyperesthesia, seizures and irritability). There is no antidote for levamisole toxicity.
The World Health Organization reviewed hematological studies in animals and humans and derived acceptable daily intake for levamisole as 0.006 mg/kg body weight. This suggests a person can ingest 0.36 mg of levamisole/day over a lifetime without any appreciable risk.
levamisole | | References | [1] Patent: CN104230959, 2016, B. Location in patent: Paragraph 0021; 0022 |
| | Levamisole hydrochloride Preparation Products And Raw materials |
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