- Cryptochlorogenic acid
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- $0.00 / 1KG
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2025-12-24
- CAS:905-99-7
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 1000KG
- Cryptochlorogenic acid
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- $0.00 / 20mg
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2023-02-24
- CAS:905-99-7
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
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| | Cryptochlorogenic acid Basic information |
| | Cryptochlorogenic acid Chemical Properties |
| Boiling point | 694.9±55.0 °C(Predicted) | | density | 1.65 | | storage temp. | 2-8°C | | solubility | DMSO : 50 mg/mL (141.12 mM; Need ultrasonic) | | form | Solid | | pka | 4.07±0.50(Predicted) | | color | White-pale yellow | | Optical Rotation | [α]/D -76.0±5.0°, c = 0.5 in H2O | | Stability: | Hygroscopic | | InChI | InChI=1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(21)25-14-11(19)6-16(24,15(22)23)7-12(14)20/h1-5,11-12,14,17-20,24H,6-7H2,(H,22,23)/t11-,12-,14-,16+/m1/s1 | | InChIKey | GYFFKZTYYAFCTR-NCZKRNLISA-N | | SMILES | O([C@H]1[C@@H](C[C@](C[C@H]1O)(O)C(=O)O)O)C(=O)C=CC1C=CC(=C(C=1)O)O |
| | Cryptochlorogenic acid Usage And Synthesis |
| Chemical Properties | White needle-shaped crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Eucommia ulmoides, Lonicera japonica, and Honeysuckle. | | Uses | Cryptochlorogenic acid may be used as a reference standard in the determination of cryptochlorogenic acid in the leaves of Hibiscus sabdariffa using high performance liquid chromatography coupled with mass spectrometry (HPLC-MS). | | Uses | 4-O-Caffeoylquinic acid has been used as a reference compound for the quantification in high performance liquid chromatography-diode array detector (HPLC-DAD). | | Definition | ChEBI: A cinnamate ester obtained by formal condensation of the carboxy group of trans-caffeic acid with the 4-hydroxy group of (+)-quinic acid. | | General Description | Cryptochlorogenic acid is a polyphenol, found in a variety of plants, which plays a crucial role in protection against various age-related diseases. | | Biochem/physiol Actions | 4-O-Caffeoylquinic acid (4-CQA) is a major active antioxidant marker in mulberry leaf extract. It is an inhibitor of ferroptosis hence, it is recognized as a potent anti-diabetic agent. 4-CQA plays an important role in the upregulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway. | | in vivo |
Pharmacokinetic parameters of Cryptochlorogenic acid after intragastric administration of Cryptochlorogenic acid at three dosages[2]
| Dose (mg/kg) | Cmax (μg/L) | tmax (h) | t1/2 (h) | AUC0-t (μg?h/L) | AUC0-∞ (μg?h/L) | MRT0-t (h) | MRT0-∞ (h) | | 100 | 630 | 0.33 | 2.00 | 1938.91 | 1977.70 | 3.21 | 3.51 | | 200 | 1270.09 | 0.47 | 1.97 | 3071.87 | 3179.41 | 3.23 | 3.39 | | 400 | 2582.68 | 0.44 | 2.34 | 8825.32 | 9139.54 | 3.47 | 3.93 |
| | IC 50 | HIF-1α |
| | Cryptochlorogenic acid Preparation Products And Raw materials |
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